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fan-1 Fanconi-associated nuclease;Fanconi-associated nuclease 1 homolog [ Caenorhabditis elegans ]

Gene ID: 177415, updated on 23-Jan-2025

Summary

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Official Symbol
fan-1
Official Full Name
Fanconi-associated nuclease;Fanconi-associated nuclease 1 homolog
Primary source
WormBase:WBGene00015310
Locus tag
CELE_C01G5.8
See related
AllianceGenome:WB:WBGene00015310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 5'-3' exonuclease activity; 5'-flap endonuclease activity; and flap-structured DNA binding activity. Involved in DNA repair. Located in nucleus. Is expressed in embryonic cell; germ cell; head neurons; intestine; and tail neurons. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in karyomegalic interstitial nephritis. Orthologous to human FAN1 (FANCD2 and FANCI associated nuclease 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See fan-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
14
Sequence:
Chromosome: IV; NC_003282.8 (6548686..6552511)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Adiponectin receptor protein 1;Progestin and adipoQ receptor-like protein 1 Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene Peptidase S1 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents. Kratz K, et al. Cell, 2010 Jul 9. PMID 20603016
  2. LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining. Lawrence KS, et al. J Cell Biol, 2016 Dec 19. PMID 27956467, Free PMC Article
  3. A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Smogorzewska A, et al. Mol Cell, 2010 Jul 9. PMID 20603073, Free PMC Article
  4. Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. MacKay C, et al. Cell, 2010 Jul 9. PMID 20603015, Free PMC Article
  5. Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. Wilson DM 3rd, et al. Nucleic Acids Res, 2017 Sep 19. PMID 28934497, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 5'-3' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-flap endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flap-structured DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphodiesterase I activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interstrand cross-link repair IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Fanconi-associated nuclease;Fanconi-associated nuclease 1 homolog
NP_001370919.1
  • Confirmed by transcript evidence
NP_500997.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6548686..6552511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068596.6 → NP_500997.1  Fanconi-associated nuclease 1 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500997.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90740
    Conserved Domains (1) summary
    pfam08774
    Location:751 → 858
    VRR_NUC; VRR-NUC domain

  2. NM_001383106.1 → NP_001370919.1  Fanconi-associated nuclease [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CK03
    Conserved Domains (1) summary
    cd22326
    Location:1 → 432
    FAN1-like; repair nuclease FAN1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P90740.1

Gene LinkOut

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