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metl-13 Methyltransferase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177431, updated on 2-Nov-2024

Summary

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Official Symbol
metl-13
Official Full Name
Methyltransferase domain-containing protein
Primary source
WormBase:WBGene00015282
Locus tag
CELE_C01B10.8
See related
AllianceGenome:WB:WBGene00015282
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein-lysine N-methyltransferase activity. Predicted to be involved in methylation. Is expressed in intestine. Orthologous to human METTL13 (methyltransferase 13, eEF1A N-terminus and K55). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See metl-13 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
12
Sequence:
Chromosome: IV; NC_003282.8 (6635089..6638155)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Carboxylesterase type B domain-containing protein Neighboring gene ncRNA Neighboring gene Bis(5'-adenosyl)-triphosphatase Neighboring gene Secreted protein;TransThyretin-Related family domain Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the biochemical activity and tumor-promoting role of the dual protein methyltransferase METL-13/METTL13 in Caenorhabditis elegans. Engelfriet ML, et al. PLoS One, 2023. PMID 37347777, Free PMC Article
  2. N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance. Liberman N, et al. Sci Adv, 2020 Apr. PMID 32494643, Free PMC Article
  3. Yolk-deprived Caenorhabditis elegans secure brood size at the expense of competitive fitness. Geens E, et al. Life Sci Alliance, 2023 Jun. PMID 37059473, Free PMC Article
  4. Proteomic analysis of Caenorhabditis elegans. Jeong PY, et al. Methods Mol Biol, 2009. PMID 19381582
  5. Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Tewari M, et al. Mol Cell, 2004 Feb 27. PMID 14992718

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Methyltransferase domain-containing protein
NP_501024.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6635089..6638155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068623.6 → NP_501024.1  Methyltransferase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501024.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17539
    Conserved Domains (2) summary
    pfam01564
    Location:337 → 572
    Spermine_synth; Spermine/spermidine synthase domain
    cl17173
    Location:44 → 158
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein
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