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usp-4 Ubiquitin carboxyl-terminal hydrolase [ Caenorhabditis elegans ]

Gene ID: 177437, updated on 4-Jan-2025

Summary

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Official Symbol
usp-4
Official Full Name
Ubiquitin carboxyl-terminal hydrolase
Primary source
WormBase:WBGene00019259
Locus tag
CELE_H34C03.2
See related
AllianceGenome:WB:WBGene00019259
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination and proteolysis. Orthologous to several human genes including USP4 (ubiquitin specific peptidase 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See usp-4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
13
Sequence:
Chromosome: IV; NC_003282.8 (6757311..6762602)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Spindle defective protein 3 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The deubiquitinase USP11 is a versatile and conserved regulator of autophagy. Basic M, et al. J Biol Chem, 2021 Nov. PMID 34600886, Free PMC Article
  2. SPD-3 is required for spindle alignment in Caenorhabditis elegans embryos and localizes to mitochondria. Dinkelmann MV, et al. Genetics, 2007 Nov. PMID 17947426, Free PMC Article
  3. Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans. Kahn NW, et al. Biochem J, 2008 Jan 1. PMID 17714076
  4. Rewiring of the ubiquitinated proteome determines ageing in C. elegans. Koyuncu S, et al. Nature, 2021 Aug. PMID 34321666, Free PMC Article
  5. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2017 Aug. PMID 28576864, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The deubiquitinase USP11 is a versatile and conserved regulator of autophagy.
    Title: The deubiquitinase USP11 is a versatile and conserved regulator of autophagy.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ubiquitin carboxyl-terminal hydrolase
NP_001293696.1
  • Confirmed by transcript evidence
NP_501035.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6757311..6762602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068634.8 → NP_501035.1  Ubiquitin carboxyl-terminal hydrolase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501035.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TYY8
    Conserved Domains (3) summary
    smart00695
    Location:51 → 135
    DUSP; Domain in ubiquitin-specific proteases
    COG5560
    Location:52 → 847
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:697 → 845
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

  2. NM_001306767.3 → NP_001293696.1  Ubiquitin carboxyl-terminal hydrolase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293696.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CJY2
    Conserved Domains (2) summary
    smart00695
    Location:51 → 135
    DUSP; Domain in ubiquitin-specific proteases
    COG5560
    Location:353 → 927
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
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