T22D1.3 CBS domain-containing protein;Inosine-5'-monophosphate dehydrogenase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: T22D1.3
Official Full Name: CBS domain-containing protein;Inosine-5'-monophosphate dehydrogenase
Primary source: WormBase:WBGene00020682
Locus tag: CELE_T22D1.3
See related: AllianceGenome:WB:WBGene00020682
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable IMP dehydrogenase activity. Predicted to be involved in GTP biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including intestine; nervous system; non-striated muscle; seam cell; and tail. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to several human genes including IMPDH1 (inosine monophosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See T22D1.3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (6913538..6917112)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T22D1.3 (e-PCR)
- UniSTS:306286

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables IMP dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables IMP dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GTP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CBS domain-containing protein;Inosine-5'-monophosphate dehydrogenase

NP_001023395.1

Confirmed by transcript evidence

NP_001293729.1

Confirmed by transcript evidence

NP_001368380.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6913538..6917112

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001306800.3 → NP_001293729.1 Inosine-5'-monophosphate dehydrogenase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293729.1

Status: REVIEWED

UniProtKB/TrEMBL

V6CLC6

Conserved Domains (1) summary

PTZ00314
Location:16 → 518

PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional
NM_001028224.4 → NP_001023395.1 Inosine-5'-monophosphate dehydrogenase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023395.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9GZH3

Conserved Domains (3) summary

cd00381
Location:31 → 513

IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...

cd04602
Location:118 → 248

CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...

PTZ00314
Location:16 → 530

PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional
NM_001380295.1 → NP_001368380.1 CBS domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CIZ1

Conserved Domains (1) summary

PTZ00314
Location:1 → 334

PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional