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jnk-1 Stress-activated protein kinase jnk-1 [ Caenorhabditis elegans ]

Gene ID: 177460, updated on 9-Dec-2024

Summary

Official Symbol
jnk-1
Official Full Name
Stress-activated protein kinase jnk-1
Primary source
WormBase:WBGene00002178
Locus tag
CELE_B0478.1
See related
AllianceGenome:WB:WBGene00002178
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables JUN kinase activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of cellular response to manganese ion; and vesicle transport along actin filament. Located in several cellular components, including axon; neuronal cell body; and nucleus. Is expressed in neurons. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; chronic mucocutaneous candidiasis; intestinal benign neoplasm (multiple); pancreatic adenocarcinoma; and type 2 diabetes mellitus. Orthologous to human MAPK10 (mitogen-activated protein kinase 10); MAPK8 (mitogen-activated protein kinase 8); and MAPK9 (mitogen-activated protein kinase 9). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See jnk-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
11
Sequence:
Chromosome: IV; NC_003282.8 (6957641..6963719)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Glycosyltransferase family 92 protein ZK381.2 Neighboring gene ncRNA Neighboring gene Glycosyltransferase family 92 protein Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hyperosmotic response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cellular response to manganese ion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cellular response to manganese ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sleep IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle transport along actin filament IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Stress-activated protein kinase jnk-1
NP_001021270.1
  • Confirmed by transcript evidence
NP_001379581.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6957641..6963719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026099.6NP_001021270.1  Stress-activated protein kinase jnk-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021270.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17507, Q8WQG9, Q9UAH2
    Conserved Domains (2) summary
    smart00220
    Location:119414
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:118452
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  2. NM_001392324.1NP_001379581.1  Stress-activated protein kinase jnk-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd07850
    Location:27361
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RNA

  1. NR_131561.1 RNA Sequence

    Status: REVIEWED