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prkl-1 LIM zinc-binding domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177463, updated on 4-Jan-2025

Summary

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Official Symbol
prkl-1
Official Full Name
LIM zinc-binding domain-containing protein
Primary source
WormBase:WBGene00022727
Locus tag
CELE_ZK381.5
See related
AllianceGenome:WB:WBGene00022727
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable zinc ion binding activity. Is expressed in several structures, including QL; egg-laying apparatus; gonad; head; and somatic nervous system. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to several human genes including PRICKLE2 (prickle planar cell polarity protein 2) and PRICKLE3 (prickle planar cell polarity protein 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See prkl-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (6978742..6986935, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Guanyl-specific ribonuclease pgl-1 Neighboring gene HORMA domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PCP and SAX-3/Robo Pathways Cooperate to Regulate Convergent Extension-Based Nerve Cord Assembly in C. elegans. Shah PK, et al. Dev Cell, 2017 Apr 24. PMID 28441532, Free PMC Article
  2. A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans. Carr D, et al. PLoS One, 2016. PMID 27300162, Free PMC Article
  3. VANG-1 and PRKL-1 cooperate to negatively regulate neurite formation in Caenorhabditis elegans. Sanchez-Alvarez L, et al. PLoS Genet, 2011 Sep. PMID 21912529, Free PMC Article
  4. Wnt Signaling Drives Ectopic Gene Expression and Larval Arrest in the Absence of the Caenorhabditis elegans DREAM Repressor Complex. Cherian JR, et al. G3 (Bethesda), 2020 Feb 6. PMID 31843805, Free PMC Article
  5. Dishevelled attenuates the repelling activity of Wnt signaling during neurite outgrowth in Caenorhabditis elegans. Zheng C, et al. Proc Natl Acad Sci U S A, 2015 Oct 27. PMID 26460008, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
LIM zinc-binding domain-containing protein
NP_741435.2
  • Confirmed by transcript evidence
NP_741436.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    6978742..6986935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171372.3 → NP_741435.2  LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741435.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYA1
    Conserved Domains (4) summary
    cd09340
    Location:149 → 204
    LIM1_Testin_like; The first LIM domain of Testin-like family
    cd09341
    Location:210 → 262
    LIM2_Testin_like; The second LIM domain of Testin-like family
    cd09827
    Location:48 → 144
    PET_Prickle; The PET domain of Prickle
    cl02475
    Location:283 → 324
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. NM_171373.6 → NP_741436.2  LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741436.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WFL0
    Conserved Domains (3) summary
    cd09340
    Location:36 → 90
    LIM1_Testin_like; The first LIM domain of Testin-like family
    cd09341
    Location:96 → 148
    LIM2_Testin_like; The second LIM domain of Testin-like family
    cl02475
    Location:169 → 210
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein
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