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rod-1 Kinetochore-associated protein rod-1 [ Caenorhabditis elegans ]

Gene ID: 177520, updated on 4-Jan-2025

Summary

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Official Symbol
rod-1
Official Full Name
Kinetochore-associated protein rod-1
Primary source
WormBase:WBGene00018900
Locus tag
CELE_F55G1.4
See related
AllianceGenome:WB:WBGene00018900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein domain specific binding activity. Involved in several processes, including chromosome organization; positive regulation of kinetochore assembly; and regulation of cell cycle process. Part of RZZ complex. Orthologous to human KNTC1 (kinetochore associated 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See rod-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
16
Sequence:
Chromosome: IV; NC_003282.8 (7478452..7485327)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene RING-CH-type domain-containing protein Neighboring gene SLC (SoLute Carrier) homolog Neighboring gene Putative pyrroline-5-carboxylate reductase 4 Neighboring gene Histone H2A Neighboring gene putative histone H2B 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Disordered Spindly C-terminus Interacts with RZZ Subunits ROD-1 and ZWL-1 in the Kinetochore through the Same Sites in C. Elegans. Henen MA, et al. J Mol Biol, 2021 Feb 19. PMID 33450249, Free PMC Article
  2. Self-Assembly of the RZZ Complex into Filaments Drives Kinetochore Expansion in the Absence of Microtubule Attachment. Pereira C, et al. Curr Biol, 2018 Nov 5. PMID 30415699, Free PMC Article
  3. Molecular mechanism of dynein recruitment to kinetochores by the Rod-Zw10-Zwilch complex and Spindly. Gama JB, et al. J Cell Biol, 2017 Apr 3. PMID 28320824, Free PMC Article
  4. Microtubules oppose cortical actomyosin-driven membrane ingression during C. elegans meiosis I polar body extrusion. Quiogue AR, et al. PLoS Genet, 2023 Oct. PMID 37782660, Free PMC Article
  5. Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation. Cheerambathur DK, et al. Science, 2013 Dec 6. PMID 24231804, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in activation of mitotic cell cycle spindle assembly checkpoint IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic chromosome movement towards spindle pole IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of kinetochore assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of mitotic sister chromatid separation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of mitotic spindle pole body separation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of mitotic spindle pole body separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to kinetochore IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to kinetochore involved in kinetochore assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to kinetochore involved in kinetochore assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of attachment of mitotic spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RZZ complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RZZ complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinetochore microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Kinetochore-associated protein rod-1
NP_501200.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7478452..7485327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068799.8 → NP_501200.1  Kinetochore-associated protein rod-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501200.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20849
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20849.1

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