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ntp-1 Nucleoside-triphosphatase ntp-1 [ Caenorhabditis elegans ]

Gene ID: 177567, updated on 4-Jan-2025

Summary

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Official Symbol
ntp-1
Official Full Name
Nucleoside-triphosphatase ntp-1
Primary source
WormBase:WBGene00016380
Locus tag
CELE_C33H5.14
See related
AllianceGenome:WB:WBGene00016380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables pyrophosphatase activity. Involved in ribonucleotide metabolic process. Located in Golgi apparatus and perinuclear region of cytoplasm. Orthologous to human ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4) and ENTPD7 (ectonucleoside triphosphate diphosphohydrolase 7). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ntp-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (7792349..7794809, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene putative splicing factor, arginine/serine-rich 6 Neighboring gene CYSTM domain-containing protein Neighboring gene Shugoshin Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans. Uccelletti D, et al. J Biol Chem, 2004 Jun 25. PMID 15102851
  2. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables CTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside triphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoside triphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ATP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in CTP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CTP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GDP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GTP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UDP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Nucleoside-triphosphatase ntp-1
NP_001294166.1
  • Confirmed by transcript evidence
NP_001294167.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7792349..7794809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001307238.2 → NP_001294167.1  Nucleoside-triphosphatase ntp-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294167.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18411, W6RRY0, W6RTH8
    Conserved Domains (1) summary
    pfam01150
    Location:74 → 492
    GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family

  2. NM_001307237.2 → NP_001294166.1  Nucleoside-triphosphatase ntp-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294166.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18411
    Conserved Domains (1) summary
    pfam01150
    Location:40 → 458
    GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18411.2

Gene LinkOut

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