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exc-9 LIM zinc-binding domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177586, updated on 4-Jan-2025

Summary

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Official Symbol
exc-9
Official Full Name
LIM zinc-binding domain-containing protein
Primary source
WormBase:WBGene00017644
Locus tag
CELE_F20D12.5
See related
AllianceGenome:WB:WBGene00017644
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable zinc ion binding activity. Involved in several processes, including body morphogenesis; morphogenesis of a polarized epithelium; and nematode male tail tip morphogenesis. Located in cytoplasm. Is expressed in several structures, including ALM; distal tip cell; excretory canal; lumbar ganglion; and nerve ring. Orthologous to human CRIP1 (cysteine rich protein 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See exc-9 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (7939812..7941019, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ion_trans domain-containing protein Neighboring gene ncRNA Neighboring gene Centromere/kinetochore protein zw10 homolog Neighboring gene Uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Terminal web and vesicle trafficking proteins mediate nematode single-cell tubulogenesis. Yang Z, et al. J Cell Biol, 2020 Nov 2. PMID 32860501, Free PMC Article
  2. Facilitation of Endosomal Recycling by an IRG Protein Homolog Maintains Apical Tubule Structure in Caenorhabditis elegans. Grussendorf KA, et al. Genetics, 2016 Aug. PMID 27334269, Free PMC Article
  3. A role for the C. elegans L1CAM homologue lad-1/sax-7 in maintaining tissue attachment. Wang X, et al. Dev Biol, 2005 Aug 15. PMID 16023097
  4. CRIP homologues maintain apical cytoskeleton to regulate tubule size in C. elegans. Tong X, et al. Dev Biol, 2008 May 1. PMID 18384766, Free PMC Article
  5. Cystic canal mutants in Caenorhabditis elegans are defective in the apical membrane domain of the renal (excretory) cell. Buechner M, et al. Dev Biol, 1999 Oct 1. PMID 10491271

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in morphogenesis of a polarized epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
LIM zinc-binding domain-containing protein
NP_501326.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7939812..7941019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068925.6 → NP_501326.2  LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501326.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19641
    Conserved Domains (1) summary
    cd09401
    Location:4 → 58
    LIM_TLP_like; The LIM domains of thymus LIM protein (TLP)
Nucleotide Protein
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