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pct-1 Cyclin-dependent kinase 17 [ Caenorhabditis elegans ]

Gene ID: 177615, updated on 4-Jan-2025

Summary

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Official Symbol
pct-1
Official Full Name
Cyclin-dependent kinase 17
Primary source
WormBase:WBGene00003961
Locus tag
CELE_C07G1.3
See related
AllianceGenome:WB:WBGene00003961
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle phase transition. Located in axon and dendrite. Orthologous to several human genes including CDK16 (cyclin dependent kinase 16). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pct-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
12
Sequence:
Chromosome: IV; NC_003282.8 (8176482..8188882)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CRIB domain-containing protein Neighboring gene ncRNA Neighboring gene Glutaredoxin domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Axonal transport: CDKs as traffic signals for motor-ists along the axon? Holzbaur E. Curr Biol, 2010 Aug 10. PMID 20692613
  2. Two cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components. Ou CY, et al. Cell, 2010 May 28. PMID 20510931, Free PMC Article
  3. Ubiquitin ligase activity inhibits Cdk5 to control axon termination. Desbois M, et al. PLoS Genet, 2022 Apr. PMID 35421092, Free PMC Article
  4. Germline stem cell integrity and quiescence are controlled by an AMPK-dependent neuronal trafficking pathway. Wong C, et al. PLoS Genet, 2023 Apr. PMID 37058536, Free PMC Article
  5. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Cyclin-dependent kinase 17
NP_001379548.1
  • Confirmed by transcript evidence
NP_501372.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8176482..8188882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068971.8 → NP_501372.1  Cyclin-dependent kinase 17 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501372.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8I7M8
    Conserved Domains (2) summary
    PLN00009
    Location:235 → 524
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07844
    Location:237 → 519
    STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases

  2. NM_001392344.1 → NP_001379548.1  Cyclin-dependent kinase 17 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EDS3, Q8I7M8
    Conserved Domains (1) summary
    cd07844
    Location:327 → 609
    STKc_PCTAIRE_like; Catalytic domain of PCTAIRE-like Serine/Threonine Kinases

RNA

  1. NR_131581.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8I7M8.1

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