dgk-4 Diacylglycerol kinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dgk-4
Official Full Name: Diacylglycerol kinase
Primary source: WormBase:WBGene00006483
Locus tag: CELE_F42A9.1
See related: AllianceGenome:WB:WBGene00006483
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in diacylglycerol metabolic process; intracellular signal transduction; and phosphatidic acid biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including anal depressor muscle; excretory cell; intestine; nervous system; and reproductive system. Orthologous to several human genes including DGKD (diacylglycerol kinase delta) and DGKH (diacylglycerol kinase eta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dgk-4 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 19

Sequence:: Chromosome: IV; NC_003282.8 (8631333..8644019)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F42A9.1 (e-PCR)
- UniSTS:317490

F42A9.9 (e-PCR)
- UniSTS:319336

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent diacylglycerol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent diacylglycerol kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in diacylglycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidic acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Diacylglycerol kinase

NP_501476.2

Confirmed by transcript evidence

NP_501477.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8631333..8644019

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069076.5 → NP_501477.2 Diacylglycerol kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501477.2

Status: REVIEWED

UniProtKB/TrEMBL

D5MCN8

Conserved Domains (6) summary

cd09507
Location:1135 → 1199

SAM_DGK-delta-eta; SAM domain of diacylglycerol kinase delta and eta subunits

smart00109
Location:121 → 171

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

smart00454
Location:1137 → 1202

SAM; Sterile alpha motif

smart00045
Location:755 → 914

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:213 → 335

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00029
Location:48 → 97

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
NM_069075.7 → NP_501476.2 Diacylglycerol kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501476.2

Status: REVIEWED

UniProtKB/TrEMBL

H2KZC9

Conserved Domains (6) summary

cd09507
Location:1186 → 1250

SAM_DGK-delta-eta; SAM domain of diacylglycerol kinase delta and eta subunits

smart00109
Location:121 → 171

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

smart00454
Location:1188 → 1253

SAM; Sterile alpha motif

smart00045
Location:806 → 965

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:213 → 335

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00029
Location:48 → 97

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...