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F21D5.6 Ribonuclease H2 subunit B wHTH domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177682, updated on 9-Dec-2024

Summary

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Official Symbol
F21D5.6
Official Full Name
Ribonuclease H2 subunit B wHTH domain-containing protein
Primary source
WormBase:WBGene00009011
Locus tag
CELE_F21D5.6
See related
AllianceGenome:WB:WBGene00009011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in RNA catabolic process. Predicted to be part of ribonuclease H2 complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2B (ribonuclease H2 subunit B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See F21D5.6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (8740140..8741388, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene HTH CENPB-type domain-containing protein Neighboring gene Small ribosomal subunit protein mS33 Neighboring gene Signal recognition particle 54 kDa protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonuclease H2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonuclease H2 complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ribonuclease H2 subunit B wHTH domain-containing protein
NP_001379087.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8740140..8741388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392356.1 → NP_001379087.1  Ribonuclease H2 subunit B wHTH domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19684
    Conserved Domains (1) summary
    cd09270
    Location:41 → 286
    RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids
Nucleotide Protein
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