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C53B4.3 Major facilitator superfamily (MFS) profile domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177714, updated on 9-Dec-2024

Summary

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Official Symbol
C53B4.3
Official Full Name
Major facilitator superfamily (MFS) profile domain-containing protein
Primary source
WormBase:WBGene00008273
Locus tag
CELE_C53B4.3
See related
AllianceGenome:WB:WBGene00008273
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Located in nucleus. Used to study cancer. Human ortholog(s) of this gene implicated in breast cancer; esophagus adenocarcinoma; and lung cancer. Orthologous to human SLC22A18 (solute carrier family 22 member 18). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See C53B4.3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (8970869..8973316, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene DUF4776 domain-containing protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene PDZ Domain containing Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene UAA transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
Major facilitator superfamily (MFS) profile domain-containing protein
NP_501557.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8970869..8973316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069156.5 → NP_501557.2  Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501557.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18797
    Conserved Domains (1) summary
    cd17331
    Location:19 → 401
    MFS_SLC22A18; Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters
Nucleotide Protein
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