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col-119 Nematode cuticle collagen N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177715, updated on 2-Nov-2024

Summary

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Official Symbol
col-119
Official Full Name
Nematode cuticle collagen N-terminal domain-containing protein
Primary source
WormBase:WBGene00000693
Locus tag
CELE_C53B4.5
See related
AllianceGenome:WB:WBGene00000693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be a structural constituent of cuticle. Predicted to be located in membrane. Predicted to be part of collagen trimer. Human ortholog(s) of this gene implicated in atherosclerosis; brain small vessel disease 2; porencephaly; and uterine fibroid. Orthologous to human COL4A2 (collagen type IV alpha 2 chain). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See col-119 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_003282.8 (8978926..8979795, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene PDZ Domain containing Neighboring gene UAA transporter Neighboring gene GDP-mannose 4,6 dehydratase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial dysfunction causes Ca(2+) overload and ECM degradation-mediated muscle damage in C. elegans. Sudevan S, et al. FASEB J, 2019 Aug. PMID 31162948, Free PMC Article
  2. NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis. Gao J, et al. PLoS Genet, 2015 Mar. PMID 25768301, Free PMC Article
  3. Identification of cross-linked peptides from complex samples. Yang B, et al. Nat Methods, 2012 Sep. PMID 22772728
  4. Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Tewari M, et al. Mol Cell, 2004 Feb 27. PMID 14992718
  5. Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression. Halaschek-Wiener J, et al. Genome Res, 2005 May. PMID 15837805, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables structural constituent of cuticle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nematode cuticle collagen N-terminal domain-containing protein
NP_501561.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8978926..8979795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069160.6 → NP_501561.1  Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501561.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18799
    Conserved Domains (3) summary
    pfam01391
    Location:206 → 265
    Collagen; Collagen triple helix repeat (20 copies)
    smart01088
    Location:12 → 64
    Col_cuticle_N; Nematode cuticle collagen N-terminal domain
    PRK07764
    Location:92 → 259
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
Nucleotide Protein
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