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pdzd-8 PDZ Domain containing [ Caenorhabditis elegans ]

Gene ID: 177716, updated on 9-Dec-2024

Summary

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Official Symbol
pdzd-8
Official Full Name
PDZ Domain containing
Primary source
WormBase:WBGene00008274
Locus tag
CELE_C53B4.4
See related
AllianceGenome:WB:WBGene00008274
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable lipid binding activity and metal ion binding activity. Predicted to be involved in mitochondrial calcium ion homeostasis and mitochondrion-endoplasmic reticulum membrane tethering. Predicted to be located in mitochondrion. Predicted to be active in mitochondria-associated endoplasmic reticulum membrane contact site. Orthologous to human PDZD8 (PDZ domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pdzd-8 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
18
Sequence:
Chromosome: IV; NC_003282.8 (8975526..8984579)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene UAA transporter Neighboring gene GDP-mannose 4,6 dehydratase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PDZD-8 and TEX-2 regulate endosomal PI(4,5)P(2) homeostasis via lipid transport to promote embryogenesis in C. elegans. Jeyasimman D, et al. Nat Commun, 2021 Oct 18. PMID 34663803, Free PMC Article
  2. A specificity map for the PDZ domain family. Tonikian R, et al. PLoS Biol, 2008 Sep 30. PMID 18828675, Free PMC Article
  3. Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Shen X, et al. Cell Calcium, 2008 May. PMID 17854888
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PDZD-8 and TEX-2 regulate endosomal PI(4,5)P2 homeostasis via lipid transport to promote embryogenesis in C. elegans.
    Title: PDZD-8 and TEX-2 regulate endosomal PI(4,5)P(2) homeostasis via lipid transport to promote embryogenesis in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion-endoplasmic reticulum membrane tethering IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion-endoplasmic reticulum membrane tethering IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondria-associated endoplasmic reticulum membrane contact site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondria-associated endoplasmic reticulum membrane contact site IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
PDZ Domain containing
NP_001023093.1
  • Confirmed by transcript evidence
NP_001122764.2
  • Confirmed by transcript evidence
NP_001294056.1
  • Confirmed by transcript evidence
NP_001294057.1
  • Confirmed by transcript evidence
NP_001360495.1
  • Confirmed by transcript evidence
NP_001360496.1
  • Confirmed by transcript evidence
NP_001360497.1
  • Confirmed by transcript evidence
NP_001360498.1
  • Confirmed by transcript evidence
NP_001360499.1
  • Confirmed by transcript evidence
NP_501558.2
  • Confirmed by transcript evidence
NP_501559.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8975526..8984579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129292.5 → NP_001122764.2  PDZ Domain containing [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122764.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5JYS5
    Conserved Domains (2) summary
    smart00228
    Location:354 → 414
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00029
    Location:995 → 1040
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  2. NM_001372894.3 → NP_001360498.1  PDZ Domain containing [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WTK6
    Conserved Domains (3) summary
    smart00228
    Location:354 → 414
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00029
    Location:997 → 1042
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    TIGR02037
    Location:347 → 492
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

  3. NM_001372897.2 → NP_001360496.1  PDZ Domain containing [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WWK3
    Conserved Domains (3) summary
    smart00228
    Location:354 → 414
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00029
    Location:997 → 1042
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    TIGR02037
    Location:347 → 492
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

  4. NM_001372898.2 → NP_001360497.1  PDZ Domain containing [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WXK7
    Conserved Domains (3) summary
    smart00228
    Location:354 → 414
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00029
    Location:995 → 1040
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    TIGR02037
    Location:347 → 492
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

  5. NM_001372896.2 → NP_001360495.1  PDZ Domain containing [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WVD0
    Conserved Domains (3) summary
    smart00228
    Location:354 → 414
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00029
    Location:997 → 1042
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    TIGR02037
    Location:347 → 492
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

  6. NM_069158.5 → NP_501559.2  PDZ Domain containing [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501559.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JM28
    Conserved Domains (2) summary
    smart00228
    Location:354 → 414
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00029
    Location:995 → 1040
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  7. NM_069157.5 → NP_501558.2  PDZ Domain containing [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501558.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18798
    Conserved Domains (2) summary
    smart00228
    Location:354 → 414
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00029
    Location:997 → 1042
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  8. NM_001372895.3 → NP_001360499.1  PDZ Domain containing [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WX00
    Conserved Domains (3) summary
    smart00228
    Location:354 → 414
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00029
    Location:995 → 1040
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    TIGR02037
    Location:347 → 492
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

  9. NM_001027922.6 → NP_001023093.1  PDZ Domain containing [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023093.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5WRP6
    Conserved Domains (2) summary
    smart00228
    Location:354 → 414
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00029
    Location:936 → 981
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

  10. NM_001307128.3 → NP_001294057.1  PDZ Domain containing [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294057.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5LXA1
    Conserved Domains (3) summary
    smart00109
    Location:938 → 983
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00228
    Location:354 → 414
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd21674
    Location:68 → 258
    SMP_PDZD8; synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in PDZ domain-containing protein 8 (PDZD8) and similar proteins

  11. NM_001307127.3 → NP_001294056.1  PDZ Domain containing [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294056.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5LQ14
    Conserved Domains (3) summary
    smart00109
    Location:936 → 981
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00228
    Location:354 → 414
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd21674
    Location:68 → 258
    SMP_PDZD8; synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in PDZ domain-containing protein 8 (PDZD8) and similar proteins
Nucleotide Protein
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