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bre-1 GDP-mannose 4,6 dehydratase 1 [ Caenorhabditis elegans ]

Gene ID: 177717, updated on 14-Nov-2024

Summary

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Official Symbol
bre-1
Official Full Name
GDP-mannose 4,6 dehydratase 1
Primary source
WormBase:WBGene00000266
Locus tag
CELE_C53B4.7
See related
AllianceGenome:WB:WBGene00000266
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables GDP-mannose 4,6-dehydratase activity. Involved in GDP-L-fucose biosynthetic process; GDP-mannose metabolic process; and response to toxic substance. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Is expressed in body wall musculature; intestine; and nervous system. Human ortholog(s) of this gene implicated in open-angle glaucoma. Orthologous to human GMDS (GDP-mannose 4,6-dehydratase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See bre-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
10
Sequence:
Chromosome: IV; NC_003282.8 (8987266..8990444)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene PDZ Domain containing Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene UAA transporter Neighboring gene ncRNA Neighboring gene MLt-TeN (mlt-10) related Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Adaptation of the "in-gel release method" to N-glycome analysis of low-milligram amounts of material. Rendić D, et al. Electrophoresis, 2007 Dec. PMID 18041037
  2. Plasticity of the β-trefoil protein fold in the recognition and control of invertebrate predators and parasites by a fungal defence system. Schubert M, et al. PLoS Pathog, 2012. PMID 22615566, Free PMC Article
  3. Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose. Barrows BD, et al. J Biol Chem, 2007 Feb 2. PMID 17135259
  4. Nematotoxicity of Marasmius oreades agglutinin (MOA) depends on glycolipid binding and cysteine protease activity. Wohlschlager T, et al. J Biol Chem, 2011 Sep 2. PMID 21757752, Free PMC Article
  5. Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans. Marroquin LD, et al. Genetics, 2000 Aug. PMID 10924467, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cloning, purification and charactrization of gmd-1
    Title: Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GDP-mannose 4,6-dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP-mannose 4,6-dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP-mannose 4,6-dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' GDP-L-fucose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' GDP-L-fucose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GDP-L-fucose biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GDP-L-fucose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GDP-mannose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GDP-mannose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in endoplasmic reticulum unfolded protein response HEP PubMed 
involved_in response to toxic substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in sarcomere HDA PubMed 
located_in striated muscle dense body HDA PubMed 

General protein information

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Preferred Names
GDP-mannose 4,6 dehydratase 1
NP_001076668.1
  • Confirmed by transcript evidence
NP_001076669.1
  • Confirmed by transcript evidence
NP_001076670.1
  • Confirmed by transcript evidence
NP_501563.1
  • Confirmed by transcript evidence
NP_501564.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8987266..8990444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069162.10 → NP_501563.1  GDP-mannose 4,6 dehydratase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501563.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18801
    Conserved Domains (2) summary
    COG1089
    Location:36 → 375
    Gmd; GDP-D-mannose dehydratase [Cell wall/membrane/envelope biogenesis]
    pfam16363
    Location:39 → 370
    GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase

  2. NM_001083201.4 → NP_001076670.1  GDP-mannose 4,6 dehydratase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076670.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18801
    Conserved Domains (2) summary
    COG1089
    Location:46 → 385
    Gmd; GDP-D-mannose dehydratase [Cell wall/membrane/envelope biogenesis]
    pfam16363
    Location:49 → 380
    GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase

  3. NM_069163.5 → NP_501564.1  GDP-mannose 4,6 dehydratase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501564.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q067Y3, Q067Y4, Q067Y5, Q18801, Q1H8X5, Q1H8X6, Q8T8N2, Q8T8N3
    Conserved Domains (2) summary
    COG1089
    Location:51 → 390
    Gmd; GDP-D-mannose dehydratase [Cell wall/membrane/envelope biogenesis]
    pfam16363
    Location:54 → 385
    GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase

  4. NM_001083200.4 → NP_001076669.1  GDP-mannose 4,6 dehydratase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076669.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18801
    Conserved Domains (2) summary
    COG1089
    Location:34 → 373
    Gmd; GDP-D-mannose dehydratase [Cell wall/membrane/envelope biogenesis]
    pfam16363
    Location:37 → 368
    GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase

  5. NM_001083199.4 → NP_001076668.1  GDP-mannose 4,6 dehydratase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076668.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18801
    Conserved Domains (2) summary
    COG1089
    Location:20 → 359
    Gmd; GDP-D-mannose dehydratase [Cell wall/membrane/envelope biogenesis]
    pfam16363
    Location:23 → 354
    GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18801.3

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