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icln-1 Methylosome subunit pICln [ Caenorhabditis elegans ]

Gene ID: 177730, updated on 4-Jan-2025

Summary

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Official Symbol
icln-1
Official Full Name
Methylosome subunit pICln
Primary source
WormBase:WBGene00002046
Locus tag
CELE_C01F6.8
See related
AllianceGenome:WB:WBGene00002046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in mRNA cis splicing, via spliceosome and spliceosomal snRNP assembly. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Predicted to be part of pICln-Sm protein complex and spliceosomal complex. Predicted to be active in cytosol. Orthologous to human CLNS1A (chloride nucleotide-sensitive channel 1A). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See icln-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (9094552..9095653, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial Neighboring gene Large ribosomal subunit protein mL42 Neighboring gene 4F5 domain-containing protein;Small EDRK-rich factor-like N-terminal domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ICln ion channel splice variants in Caenorhabditis elegans: voltage dependence and interaction with an operon partner protein. Fürst J, et al. J Biol Chem, 2002 Feb 8. PMID 11706026
  2. Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. Kwon JY, et al. Genomics, 2004 Apr. PMID 15028283
  3. A new gene-finding tool: using the Caenorhabditis elegans operons for identifying functional partner proteins in human cells. Eichmüller S, et al. J Biol Chem, 2004 Feb 20. PMID 14615488
  4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in cell volume homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal snRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal snRNP assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
part_of methylosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of pICln-Sm protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of pICln-Sm protein complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Methylosome subunit pICln
NP_001021288.1
  • Partially confirmed by transcript evidence
NP_001379098.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9094552..9095653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392361.1 → NP_001379098.1  Methylosome subunit pICln [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFZ5
    Conserved Domains (1) summary
    pfam03517
    Location:32 → 140
    Voldacs; Regulator of volume decrease after cellular swelling

  2. NM_001026117.4 → NP_001021288.1  Methylosome subunit pICln [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021288.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EG22
    Conserved Domains (1) summary
    pfam03517
    Location:32 → 160
    Voldacs; Regulator of volume decrease after cellular swelling
Nucleotide Protein
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