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aly-2 Chromatin target of PRMT1 protein C-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177738, updated on 2-Nov-2024

Summary

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Official Symbol
aly-2
Official Full Name
Chromatin target of PRMT1 protein C-terminal domain-containing protein
Primary source
WormBase:WBGene00000121
Locus tag
CELE_F23B2.6
See related
AllianceGenome:WB:WBGene00000121
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be active in nucleus. Is expressed in several structures, including anal region; digestive tract; germ line; gonadal primordium; and midbody. Orthologous to human ALYREF (Aly/REF export factor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See aly-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (9147468..9148579)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Intraflagellar transport protein 122 homolog Neighboring gene SQPNFLRF-amide Neighboring gene DNA-directed RNA polymerases I, II, and III subunit RPABC4 Neighboring gene pseudo Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA. Navarro IC, et al. Wellcome Open Res, 2022. PMID 37475875, Free PMC Article
  2. Loss of aly/ALYREF suppresses toxicity in both tau and TDP-43 models of neurodegeneration. Kow RL, et al. Geroscience, 2022 Apr. PMID 35122183, Free PMC Article
  3. REF-ereeing the cytoplasmic fate of mRNA via nuclear export. McKee AE, et al. Dev Cell, 2004 Jun. PMID 15177019
  4. The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development. Castellano-Pozo M, et al. PLoS One, 2012. PMID 23285047, Free PMC Article
  5. The zinc finger protein REF-2 functions with the Hox genes to inhibit cell fusion in the ventral epidermis of C. elegans. Alper S, et al. Development, 2002 Jul. PMID 12091304

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Chromatin target of PRMT1 protein C-terminal domain-containing protein
NP_501594.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9147468..9148579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069193.7 → NP_501594.1  Chromatin target of PRMT1 protein C-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501594.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O62183
    Conserved Domains (2) summary
    pfam13865
    Location:165 → 227
    FoP_duplication; C-terminal duplication domain of Friend of PRMT1
    cl17169
    Location:81 → 152
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
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