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cav-1 Caveolin;Caveolin-1 [ Caenorhabditis elegans ]

Gene ID: 177815, updated on 2-Nov-2024

Summary

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Official Symbol
cav-1
Official Full Name
Caveolin;Caveolin-1
Primary source
WormBase:WBGene00000301
Locus tag
CELE_T13F2.8
See related
AllianceGenome:WB:WBGene00000301
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable molecular adaptor activity. Involved in Ras protein signal transduction; meiotic cell cycle; and regulation of egg-laying behavior. Located in several cellular components, including cytoplasmic side of plasma membrane; cytoplasmic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including germ cell; germ line; nervous system; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscle tissue disease (multiple); and systemic scleroderma (multiple). Orthologous to several human genes including CAV1 (caveolin 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cav-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
2
Sequence:
Chromosome: IV; NC_003282.8 (9772510..9773559)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Major sperm protein 78 Neighboring gene Small Nuclear RNA (snRNA) Associated protein Neighboring gene DUF4210 domain-containing protein Neighboring gene Serpentine Receptor, class E (Epsilon)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionary analysis and molecular dissection of caveola biogenesis. Kirkham M, et al. J Cell Sci, 2008 Jun 15. PMID 18505796
  2. Caveolin, cholesterol and Ras signalling. Sternberg PW, et al. Nat Cell Biol, 1999 Jun. PMID 10559891
  3. Endogenous expression and localization of CAV-1::GFP in C. elegans. Sloan DE, et al. MicroPubl Biol, 2020 Sep 21. PMID 33005882, Free PMC Article
  4. Identification, sequence, and expression of an invertebrate caveolin gene family from the nematode Caenorhabditis elegans. Implications for the molecular evolution of mammalian caveolin genes. Tang Z, et al. J Biol Chem, 1997 Jan 24. PMID 8999956
  5. Overexpression of caveolins in Caenorhabditis elegans induces changes in egg-laying and fecundity. Parker S, et al. Commun Integr Biol, 2009 Sep. PMID 19907693, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles.
    Title: CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles.
  2. These data link RABS-5 and VPS-45 ciliary functions to the processing of periciliary-derived endocytic vesicles and regulation of ciliary membrane homeostasis. Our findings also provide insight into the regulation of PKD-2 ciliary levels via integrated endosomal sorting and CAV-1-mediated endocytosis.
    Title: Endosome maturation factors Rabenosyn-5/VPS45 and caveolin-1 regulate ciliary membrane and polycystin-2 homeostasis.
  3. The distribution of CAV-1 is highly dynamic during development and provides new insights into the sorting mechanisms that regulate CAV-1 localization.
    Title: Dynamic regulation of caveolin-1 trafficking in the germ line and embryo of Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in caveola assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in caveola assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of egg-laying behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with caveola IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in caveola IEA
Inferred from Electronic Annotation
more info
  
located_in caveola TAS
Traceable Author Statement
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cortical granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane raft HDA PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in transport vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Caveolin;Caveolin-1
NP_001255421.1
  • Confirmed by transcript evidence
NP_001255422.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9772510..9773559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268492.4 → NP_001255421.1  Caveolin-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255421.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q94051
    Conserved Domains (1) summary
    pfam01146
    Location:93 → 223
    Caveolin; Caveolin

  2. NM_001268493.3 → NP_001255422.1  Caveolin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255422.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L2G6
    Conserved Domains (1) summary
    pfam01146
    Location:1 → 114
    Caveolin; Caveolin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94051.1

Gene LinkOut

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