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pis-1 BRCT domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177818, updated on 9-Dec-2024

Summary

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Official Symbol
pis-1
Official Full Name
BRCT domain-containing protein
Primary source
WormBase:WBGene00004031
Locus tag
CELE_T13F2.3
See related
AllianceGenome:WB:WBGene00004031
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in programmed cell death. Part of MLL3/4 complex. Orthologous to human PAXIP1 (PAX interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pis-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
15
Sequence:
Chromosome: IV; NC_003282.8 (9791933..9796594, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene FTH domain-containing protein Neighboring gene Putative RNA polymerase II transcriptional coactivator Neighboring gene Delta(5) fatty acid desaturase fat-4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity. Vandamme J, et al. PLoS Genet, 2012. PMID 22570628, Free PMC Article
  2. Transcriptional control of non-apoptotic developmental cell death in C. elegans. Malin JA, et al. Cell Death Differ, 2016 Dec. PMID 27472063, Free PMC Article
  3. The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity. Snoznik C, et al. Proc Natl Acad Sci U S A, 2021 Oct 5. PMID 34593637, Free PMC Article
  4. DNA-damage-induced checkpoint pathways in the nematode Caenorhabditis elegans. Hofmann ER, et al. Cold Spring Harb Symp Quant Biol, 2000. PMID 12760063
  5. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MLL3/4 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MLL3/4 complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
BRCT domain-containing protein
NP_501748.1
  • Confirmed by transcript evidence
NP_501749.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9791933..9796594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069348.7 → NP_501749.1  BRCT domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501749.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q94046
    Conserved Domains (3) summary
    smart00292
    Location:933 → 1013
    BRCT; breast cancer carboxy-terminal domain
    cd00027
    Location:832 → 897
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam00533
    Location:613 → 692
    BRCT; BRCA1 C Terminus (BRCT) domain

  2. NM_069347.5 → NP_501748.1  BRCT domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501748.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U370
    Conserved Domains (3) summary
    smart00292
    Location:935 → 1015
    BRCT; breast cancer carboxy-terminal domain
    cd00027
    Location:834 → 899
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam00533
    Location:615 → 694
    BRCT; BRCA1 C Terminus (BRCT) domain
Nucleotide Protein
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