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kin-24 Tyrosine-protein kinase [ Caenorhabditis elegans ]

Gene ID: 177829, updated on 4-Jan-2025

Summary

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Official Symbol
kin-24
Official Full Name
Tyrosine-protein kinase
Primary source
WormBase:WBGene00002206
Locus tag
CELE_K07F5.4
See related
AllianceGenome:WB:WBGene00002206
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein tyrosine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human FER (FER tyrosine kinase) and FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See kin-24 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (9839057..9841084, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Major Sperm Protein Neighboring gene Major sperm protein 10/36/56/76 Neighboring gene Major sperm protein 10/36/56/76 Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA. Oates AC, et al. Biochem Biophys Res Commun, 1998 Aug 28. PMID 9731193
  2. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tyrosine-protein kinase
NP_501761.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9839057..9841084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069360.3 → NP_501761.2  Tyrosine-protein kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501761.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D6R8W4
    Conserved Domains (3) summary
    smart00221
    Location:157 → 414
    STYKc; Protein kinase; unclassified specificity
    smart00252
    Location:29 → 128
    SH2; Src homology 2 domains
    cd00192
    Location:157 → 414
    PTKc; Catalytic domain of Protein Tyrosine Kinases
Nucleotide Protein
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