pyp-1 Inorganic pyrophosphatase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pyp-1
Official Full Name: Inorganic pyrophosphatase 1
Primary source: WormBase:WBGene00008149
Locus tag: CELE_C47E12.4
See related: AllianceGenome:WB:WBGene00008149
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable inorganic diphosphate phosphatase activity. Involved in innate immune response. Located in neuron projection and vacuole. Is expressed in coelomocyte; intestine; and neurons. Orthologous to human PPA1 (inorganic pyrophosphatase 1) and PPA2 (inorganic pyrophosphatase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pyp-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (9995385..9998925, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

larval arrest phenotype was successfully rescued by reintroduction of the pyp-1 gene
Title: PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C. elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C47E12.4 (e-PCR)
- UniSTS:306003

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables inorganic diphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inorganic diphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	HEP more info	PubMed
involved_in phosphate-containing compound metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate-containing compound metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in vacuole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Inorganic pyrophosphatase 1

NP_001023073.1

Confirmed by transcript evidence

NP_001023075.2

Partially confirmed by transcript evidence

NP_001023076.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

9995385..9998925 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027904.7 → NP_001023075.2 Inorganic pyrophosphatase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023075.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18680, Q86DB1, Q86DB2, Q86DB3

Conserved Domains (1) summary

cl00217
Location:119 → 375

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
NM_001027902.4 → NP_001023073.1 Inorganic pyrophosphatase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023073.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18680

Conserved Domains (1) summary

cl00217
Location:25 → 286

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.
NM_001027905.7 → NP_001023076.1 Inorganic pyrophosphatase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023076.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18680

Conserved Domains (1) summary

cl00217
Location:2 → 240

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.