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egl-38 Paired box protein 5 homolog [ Caenorhabditis elegans ]

Gene ID: 177876, updated on 9-Dec-2024

Summary

Official Symbol
egl-38
Official Full Name
Paired box protein 5 homolog
Primary source
WormBase:WBGene00001204
Locus tag
CELE_C04G2.7
See related
AllianceGenome:WB:WBGene00001204
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including nematode male tail tip morphogenesis; uterus development; and vulval development. Located in chromatin and nucleus. Is expressed in several structures, including body wall musculature; head neurons; uv1; ventral nerve cord; and vulva. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; congenital hypothyroidism (multiple); focal segmental glomerulosclerosis 7; renal Wilms' tumor; and renal coloboma syndrome. Orthologous to human PAX2 (paired box 2); PAX5 (paired box 5); and PAX8 (paired box 8). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See egl-38 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (10106599..10110517, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Major sperm protein 10/36/56/76 Neighboring gene putative exosome complex exonuclease RRP44 Neighboring gene SPerm CHromatin enriched Neighboring gene pseudo

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Paired box protein 5 homolog
NP_501836.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10106599..10110517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069435.6NP_501836.1  Paired box protein 5 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501836.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ED14
    Conserved Domains (1) summary
    smart00351
    Location:29153
    PAX; Paired Box domain