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ptrg-1 Tyrosine-protein phosphatase 4 [ Caenorhabditis elegans ]

Gene ID: 177898, updated on 9-Dec-2024

Summary

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Official Symbol
ptrg-1
Official Full Name
Tyrosine-protein phosphatase 4
Primary source
WormBase:WBGene00010558
Locus tag
CELE_K04D7.4
See related
AllianceGenome:WB:WBGene00010558
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in neuron projection development and signal transduction. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ptrg-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
18
Sequence:
Chromosome: IV; NC_003282.8 (10183842..10194445, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Small ribosomal subunit protein RACK1 Neighboring gene Mitochondrial sorting homolog Neighboring gene putative 4-aminobutyrate aminotransferase, mitochondrial Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GON-4-like protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High neural activity accelerates the decline of cognitive plasticity with age in Caenorhabditis elegans. Li Q, et al. Elife, 2020 Nov 24. PMID 33228848, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tyrosine-protein phosphatase 4
NP_001255470.1
  • Confirmed by transcript evidence
NP_001255471.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10183842..10194445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268541.3 → NP_001255470.1  Tyrosine-protein phosphatase 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255470.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3YT39, P28192, Q21214
    Conserved Domains (5) summary
    smart00194
    Location:642 → 900
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:83 → 120
    IG_like; Immunoglobulin like
    cd00047
    Location:675 → 900
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:140 → 232
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00102
    Location:977 → 1128
    Y_phosphatase; Protein-tyrosine phosphatase

  2. NM_001268542.3 → NP_001255471.1  Tyrosine-protein phosphatase 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255471.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P28192
    Conserved Domains (5) summary
    smart00194
    Location:596 → 854
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:37 → 74
    IG_like; Immunoglobulin like
    cd00047
    Location:629 → 854
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:94 → 186
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00102
    Location:931 → 1082
    Y_phosphatase; Protein-tyrosine phosphatase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28192.3

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