nfu-1 NFU1 iron-sulfur cluster scaffold homolog, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nfu-1
Official Full Name: NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
Primary source: WormBase:WBGene00003064
Locus tag: CELE_R10H10.1
See related: AllianceGenome:WB:WBGene00003064
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 4 iron, 4 sulfur cluster binding activity. Involved in lipid storage. Predicted to be active in mitochondrion. Used to study multiple mitochondrial dysfunctions syndrome 1. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 1. Orthologous to human NFU1 (NFU1 iron-sulfur cluster scaffold). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nfu-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 4

Sequence:: Chromosome: IV; NC_003282.8 (10387413..10388336)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Allele-specific mitochondrial stress induced by Multiple Mitochondrial Dysfunctions Syndrome 1 pathogenic mutations modeled in Caenorhabditis elegans.
Title: Allele-specific mitochondrial stress induced by Multiple Mitochondrial Dysfunctions Syndrome 1 pathogenic mutations modeled in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R10H10.1 (e-PCR)
- UniSTS:320600

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein maturation by [4Fe-4S] cluster transfer	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

NP_501917.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10387413..10388336

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069516.8 → NP_501917.2 NFU1 iron-sulfur cluster scaffold homolog, mitochondrial [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q21915

Conserved Domains (2) summary

pfam01106
Location:136 → 202

NifU; NifU-like domain

pfam08712
Location:23 → 112

Nfu_N; Scaffold protein Nfu/NifU N terminal