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spe-26 Spermatocyte protein spe-26 [ Caenorhabditis elegans ]

Gene ID: 177929, updated on 23-Jan-2025

Summary

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Official Symbol
spe-26
Official Full Name
Spermatocyte protein spe-26
Primary source
WormBase:WBGene00004972
Locus tag
CELE_R10H10.2
See related
AllianceGenome:WB:WBGene00004972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoskeleton. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in spermatocyte and in male. Human ortholog(s) of this gene implicated in spermatogenic failure 11. Orthologous to human KLHL10 (kelch like family member 10). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See spe-26 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (10389578..10391927, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ankyrin repeat and KH domain-containing protein mask-1;K Homology domain-containing protein Neighboring gene NFU1 iron-sulfur cluster scaffold homolog, mitochondrial Neighboring gene CUB domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF3149 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Production of sperm reduces nematode lifespan. Van Voorhies WA. Nature, 1992 Dec 3. PMID 1448167
  2. The Caenorhabditis elegans spe-26 gene is necessary to form spermatids and encodes a protein similar to the actin-associated proteins kelch and scruin. Varkey JP, et al. Genes Dev, 1995 May 1. PMID 7744249
  3. The Caenorhabditis elegans spe-6 gene is required for major sperm protein assembly and shows second site non-complementation with an unlinked deficiency. Varkey JP, et al. Genetics, 1993 Jan. PMID 8417991, Free PMC Article
  4. Longevity in Caenorhabditis elegans reduced by mating but not gamete production. Gems D, et al. Nature, 1996 Feb 22. PMID 8602217
  5. cdh-3, a gene encoding a member of the cadherin superfamily, functions in epithelial cell morphogenesis in Caenorhabditis elegans. Pettitt J, et al. Development, 1996 Dec. PMID 9012534

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Spermatocyte protein spe-26
NP_501919.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10389578..10391927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069518.5 → NP_501919.1  Spermatocyte protein spe-26 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501919.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10579
    Conserved Domains (4) summary
    smart00612
    Location:341 → 393
    Kelch; Kelch domain
    smart00875
    Location:131 → 223
    BACK; BTB And C-terminal Kelch
    sd00038
    Location:282 → 324
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:282 → 325
    Kelch_1; Kelch motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10579.1

Gene LinkOut

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