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allo-1 Allophagy receptor allo-1 [ Caenorhabditis elegans ]

Gene ID: 177962, updated on 9-Dec-2024

Summary

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Official Symbol
allo-1
Official Full Name
Allophagy receptor allo-1
Primary source
WormBase:WBGene00011292
Locus tag
CELE_R102.5
See related
AllianceGenome:WB:WBGene00011292
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein homodimerization activity. Involved in autophagosome assembly and regulation of autophagy. Located in cytoplasm. Is expressed in oocyte. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See allo-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (10695306..10697072, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene TransThyretin-Related family domain Neighboring gene Aromatic amino acid beta-eliminating lyase/threonine aldolase domain-containing protein;Beta_elim_lyase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene MARVEL domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ALLO-1- and IKKE-1-dependent positive feedback mechanism promotes the initiation of paternal mitochondrial autophagy. Sasaki T, et al. Nat Commun, 2024 Feb 17. PMID 38368448, Free PMC Article
  2. The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans. Sato M, et al. Nat Cell Biol, 2018 Jan. PMID 29255173
  3. Domain selection combined with improved cloning strategy for high throughput expression of higher eukaryotic proteins. Chen Y, et al. BMC Biotechnol, 2007 Jul 30. PMID 17663785, Free PMC Article
  4. SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity. Lim CY, et al. Autophagy, 2023 Jan. PMID 35503435, Free PMC Article
  5. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. It has been proposed that ALLO-1 is the allophagy receptor whose function is regulated by IKKE-1-dependent phosphorylation.
    Title: The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in sarcomere HDA PubMed 
located_in striated muscle dense body HDA PubMed 

General protein information

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Preferred Names
Allophagy receptor allo-1
NP_501980.2
  • Confirmed by transcript evidence
NP_501981.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10695306..10697072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069579.6 → NP_501980.2  Allophagy receptor allo-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501980.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21891, Q9U389
    Conserved Domains (1) summary
    COG4372
    Location:144 → 378
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

  2. NM_069580.7 → NP_501981.2  Allophagy receptor allo-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501981.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21891
    Conserved Domains (1) summary
    COG4372
    Location:144 → 380
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U389.2

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