hars-1 Histidine--tRNA ligase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hars-1
Official Full Name: Histidine--tRNA ligase
Primary source: WormBase:WBGene00002001
Locus tag: CELE_T11G6.1
See related: AllianceGenome:WB:WBGene00002001
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA binding activity; histidine-tRNA ligase activity; and identical protein binding activity. Involved in germ cell development; nematode larval development; and translation. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Used to study Perrault syndrome and sensory peripheral neuropathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease, axonal type 2W; Perrault syndrome; and Usher syndrome type 3B. Orthologous to human HARS1 (histidyl-tRNA synthetase 1) and HARS2 (histidyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hars-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 6

Sequence:: Chromosome: IV; NC_003282.8 (10858957..10861284)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T11G6.1 (e-PCR)
- UniSTS:308012

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables histidine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histidine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables histidine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in histidyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in histidyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in histidyl-tRNA aminoacylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in nematode larval development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Histidine--tRNA ligase

NP_001023373.2

Confirmed by transcript evidence

NP_001023374.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10858957..10861284

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028202.5 → NP_001023373.2 Histidine--tRNA ligase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023373.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P34183

Conserved Domains (4) summary

COG0124
Location:65 → 522

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

cd00773
Location:78 → 416

HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...

cd00859
Location:427 → 518

HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

cl00349
Location:13 → 63

S15_NS1_EPRS_RNA-bind; S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic ...
NM_001028203.7 → NP_001023374.1 Histidine--tRNA ligase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023374.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34183, Q22408, Q26342, Q86DB0

Conserved Domains (3) summary

COG0124
Location:62 → 519

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

cd00773
Location:75 → 413

HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...

cd00859
Location:424 → 515

HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...