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rbm-22 Pre-mRNA-splicing factor RBM22 [ Caenorhabditis elegans ]

Gene ID: 177979, updated on 2-Nov-2024

Summary

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Official Symbol
rbm-22
Official Full Name
Pre-mRNA-splicing factor RBM22
Primary source
WormBase:WBGene00011722
Locus tag
CELE_T11G6.8
See related
AllianceGenome:WB:WBGene00011722
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable U6 snRNA binding activity and pre-mRNA binding activity. Located in nucleus. Orthologous to human RBM22 (RNA binding motif protein 22). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rbm-22 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (10861402..10864232)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Sugar phosphate exchanger 3 Neighboring gene ncRNA Neighboring gene Histidine--tRNA ligase Neighboring gene PX domain-containing protein Neighboring gene Transmembrane protein Neighboring gene Neuropeptide-Like Protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteomic analysis reveals CACN-1 is a component of the spliceosome in Caenorhabditis elegans. Doherty MF, et al. G3 (Bethesda), 2014 Jun 19. PMID 24948787, Free PMC Article
  2. The Regulatory Landscape of Lineage Differentiation in a Metazoan Embryo. Du Z, et al. Dev Cell, 2015 Sep 14. PMID 26321128, Free PMC Article
  3. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
  4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  5. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables U6 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables pre-mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type catalytic step 1 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
Pre-mRNA-splicing factor RBM22
NP_001293970.1
  • Confirmed by transcript evidence
NP_502014.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10861402..10864232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069613.9 → NP_502014.2  Pre-mRNA-splicing factor RBM22 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502014.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22412
    Conserved Domains (3) summary
    smart00356
    Location:165 → 188
    ZnF_C3H1; zinc finger
    COG0724
    Location:214 → 322
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12224
    Location:234 → 311
    RRM_RBM22; RNA recognition motif (RRM) found in Pre-mRNA-splicing factor RBM22 and similar proteins

  2. NM_001307041.3 → NP_001293970.1  Pre-mRNA-splicing factor RBM22 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293970.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ACS6
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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