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atg-7 Ubiquitin-like modifier-activating enzyme ATG7 [ Caenorhabditis elegans ]

Gene ID: 178005, updated on 9-Dec-2024

Summary

Official Symbol
atg-7
Official Full Name
Ubiquitin-like modifier-activating enzyme ATG7
Primary source
WormBase:WBGene00010882
Locus tag
CELE_M7.5
See related
AllianceGenome:WB:WBGene00010882
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable Atg12 activating enzyme activity and Atg8 activating enzyme activity. Involved in several processes, including dauer larval development; determination of adult lifespan; and positive regulation of autophagosome assembly. Predicted to be active in phagophore assembly site. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 31. Orthologous to human ATG7 (autophagy related 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See atg-7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (11078682..11081055, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene C2H2-type domain-containing protein Neighboring gene Ubiquitin-conjugating enzyme E2 2 Neighboring gene ncRNA

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables Atg12 activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Atg8 activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein modification by small protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in phagophore assembly site IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Ubiquitin-like modifier-activating enzyme ATG7
NP_502064.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11078682..11081055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069663.6NP_502064.1  Ubiquitin-like modifier-activating enzyme ATG7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502064.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBK4
    Conserved Domains (1) summary
    TIGR01381
    Location:4635
    E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p