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let-70 Ubiquitin-conjugating enzyme E2 2 [ Caenorhabditis elegans ]

Gene ID: 178006, updated on 9-Dec-2024

Summary

Official Symbol
let-70
Official Full Name
Ubiquitin-conjugating enzyme E2 2
Primary source
WormBase:WBGene00002344
Locus tag
CELE_M7.1
See related
AllianceGenome:WB:WBGene00002344
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in programmed cell death involved in cell development; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in chromosome and cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including P1; P10; linker cell; ventral ganglion; and ventral nerve cord. Orthologous to several human genes including UBE2D2 (ubiquitin conjugating enzyme E2 D2) and UBE2D3 (ubiquitin conjugating enzyme E2 D3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See let-70 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (11081086..11082253, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene Ubiquitin-like modifier-activating enzyme ATG7 Neighboring gene ncRNA Neighboring gene Kinesin light chain

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin conjugating enzyme activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in programmed cell death involved in cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Ubiquitin-conjugating enzyme E2 2
NP_502065.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11081086..11082253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069664.7NP_502065.1  Ubiquitin-conjugating enzyme E2 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502065.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35129
    Conserved Domains (1) summary
    cl00154
    Location:1146
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...