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enpl-1 Endoplasmin homolog [ Caenorhabditis elegans ]

Gene ID: 178014, updated on 2-Nov-2024

Summary

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Official Symbol
enpl-1
Official Full Name
Endoplasmin homolog
Primary source
WormBase:WBGene00011480
Locus tag
CELE_T05E11.3
See related
AllianceGenome:WB:WBGene00011480
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP binding activity; ATP hydrolysis activity; and unfolded protein binding activity. Predicted to be involved in ERAD pathway and protein folding. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum and perinuclear region of cytoplasm. Is expressed in several structures, including germ line; head; intestine; pharynx; and vulva. Used to study cardiovascular system disease. Orthologous to human HSP90B1 (heat shock protein 90 beta family member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See enpl-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (11119298..11123155)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene CLaudin-like in Caenorhabditis Neighboring gene Intramembrane protease 2 Neighboring gene DNA topoisomerase (ATP-hydrolyzing);Meiotic recombination protein spo-11 Neighboring gene SWI/SNF chromatin remodeling complex core catalytic subunit swsn-4 Neighboring gene 3-hydroxyacyl-CoA dehydrogenase;3-hydroxyacyl-CoA dehydrogenase type-2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ENPL-1, the Caenorhabditis elegans homolog of GRP94, promotes insulin secretion via regulation of proinsulin processing and maturation. Podraza-Farhanieh A, et al. Development, 2020 Oct 27. PMID 33037039, Free PMC Article
  2. Proteomics analysis in Caenorhabditis elegans to elucidate the response induced by tyrosol, an olive phenol that stimulates longevity and stress resistance. Cañuelo A, et al. Proteomics, 2013 Oct. PMID 23929540
  3. Depletion of the ER chaperone ENPL-1 sensitizes C. elegans to the anticancer drug cisplatin. Natarajan B, et al. Worm, 2013 Jan 1. PMID 24058864, Free PMC Article
  4. A proinsulin-dependent interaction between ENPL-1 and ASNA-1 in neurons is required to maintain insulin secretion in C. elegans. Podraza-Farhanieh A, et al. Development, 2023 Mar 15. PMID 36939052, Free PMC Article
  5. Expression of hepatitis B virus surface antigens induces defective gonad phenotypes in Caenorhabditis elegans. Chen YY, et al. World J Virol, 2017 Feb 12. PMID 28239568, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A proinsulin-dependent interaction between ENPL-1 and ASNA-1 in neurons is required to maintain insulin secretion in C. elegans.
    Title: A proinsulin-dependent interaction between ENPL-1 and ASNA-1 in neurons is required to maintain insulin secretion in C. elegans.
  2. ENPL-1, the Caenorhabditis elegans homolog of GRP94, promotes insulin secretion via regulation of proinsulin processing and maturation.
    Title: ENPL-1, the Caenorhabditis elegans homolog of GRP94, promotes insulin secretion via regulation of proinsulin processing and maturation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Endoplasmin homolog
NP_001255536.1
  • Confirmed by transcript evidence
NP_001255537.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11119298..11123155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268607.4 → NP_001255536.1  Endoplasmin homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255536.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E9P859, Q22235
    Conserved Domains (3) summary
    smart00387
    Location:84 → 242
    HATPase_c; Histidine kinase-like ATPases
    PRK05218
    Location:59 → 724
    PRK05218; heat shock protein 90; Provisional
    pfam00183
    Location:245 → 735
    HSP90; Hsp90 protein

  2. NM_001268608.3 → NP_001255537.1  Endoplasmin homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255537.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22235
    Conserved Domains (3) summary
    smart00387
    Location:12 → 170
    HATPase_c; Histidine kinase-like ATPases
    PRK05218
    Location:4 → 652
    PRK05218; heat shock protein 90; Provisional
    pfam00183
    Location:173 → 663
    HSP90; Hsp90 protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22235.1

Gene LinkOut

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