sart-3 Nuclear RNA-binding protein sart-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sart-3
Official Full Name: Nuclear RNA-binding protein sart-3
Primary source: WormBase:WBGene00007111
Locus tag: CELE_B0035.12
See related: AllianceGenome:WB:WBGene00007111
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables U4 snRNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Located in nucleoplasm. Orthologous to human SART3 (spliceosome associated factor 3, U4/U6 recycling protein). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See sart-3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 11

Sequence:: Chromosome: IV; NC_003282.8 (11329482..11332892, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endogenous USIP-1-U6 snRNA complexes lack the Lsm proteins that constitute the protein core of the U6 snRNP, but contain the U6 snRNP recycling factor SART3/B0035.12.
Title: The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0035.12 (e-PCR)
- UniSTS:308820

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables U4 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear RNA-binding protein sart-3

NP_502136.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11329482..11332892 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069735.8 → NP_502136.1 Nuclear RNA-binding protein sart-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502136.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17430

Conserved Domains (3) summary

COG0457
Location:209 → 494

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

pfam05391
Location:818 → 835

Lsm_interact; Lsm interaction motif

cl17169
Location:594 → 664

RRM_SF; RNA recognition motif (RRM) superfamily