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sec-31 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178060, updated on 4-Jan-2025

Summary

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Official Symbol
sec-31
Official Full Name
WD_REPEATS_REGION domain-containing protein
Primary source
WormBase:WBGene00011338
Locus tag
CELE_T01G1.3
See related
AllianceGenome:WB:WBGene00011338
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable structural molecule activity. Predicted to be involved in COPII-coated vesicle cargo loading and endoplasmic reticulum organization. Predicted to be located in endoplasmic reticulum. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Human ortholog(s) of this gene implicated in Halperin-Birk syndrome. Orthologous to several human genes including SEC31A (SEC31 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See sec-31 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
16
Sequence:
Chromosome: IV; NC_003282.8 (11365621..11371792, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene tRNA Neighboring gene Chitin-binding domain protein cbd-1 Neighboring gene F-box domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sar1 GTPase Activity Is Regulated by Membrane Curvature. Hanna MG 4th, et al. J Biol Chem, 2016 Jan 15. PMID 26546679, Free PMC Article
  2. ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans. Guan L, et al. Traffic, 2022 Mar. PMID 34994051
  3. TFG-1 function in protein secretion and oncogenesis. Witte K, et al. Nat Cell Biol, 2011 May. PMID 21478858, Free PMC Article
  4. The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response. Zhang Z, et al. PLoS Genet, 2021 Feb. PMID 33524011, Free PMC Article
  5. ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Wang W, et al. Traffic, 2008 May. PMID 18298590, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WD_REPEATS_REGION domain-containing protein
NP_502144.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11365621..11371792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069743.7 → NP_502144.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502144.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFY6
    Conserved Domains (3) summary
    sd00039
    Location:71 → 119
    7WD40; WD40 repeat [structural motif]
    pfam03154
    Location:773 → 895
    Atrophin-1; Atrophin-1 family
    cl29593
    Location:72 → 311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version

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