U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

nhx-9 putative Na(+)/H(+) antiporter nhx-9 [ Caenorhabditis elegans ]

Gene ID: 178126, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
nhx-9
Official Full Name
putative Na(+)/H(+) antiporter nhx-9
Primary source
WormBase:WBGene00003736
Locus tag
CELE_ZK822.3
See related
AllianceGenome:WB:WBGene00003736
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in excretory cell; intestine; and phasmid sensillum. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 8 and end stage renal disease. Orthologous to human SLC9A3 (solute carrier family 9 member A3) and SLC9A5 (solute carrier family 9 member A5). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See nhx-9 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
10
Sequence:
Chromosome: IV; NC_003282.8 (11930872..11935718)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein Neighboring gene tRNA-Leu Neighboring gene Sodium-dependent multivitamin transporter Neighboring gene ncRNA Neighboring gene DeHydrogenases, Short chain

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Molecular analysis of two genes between let-653 and let-56 in the unc-22(IV) region of Caenorhabditis elegans. Marra MA, et al. Mol Gen Genet, 1993 Jan. PMID 8382340
  2. Coordinate regulation of gene expression in the C. elegans excretory cell by the POU domain protein CEH-6. Armstrong KR, et al. Mol Genet Genomics, 2010 Jan. PMID 19921263
  3. The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy. Sewell AK, et al. iScience, 2022 May 20. PMID 35479415, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium:proton antiporter activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of pH IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
putative Na(+)/H(+) antiporter nhx-9
NP_001023627.1
  • Confirmed by transcript evidence
NP_001023628.1
  • Confirmed by transcript evidence
NP_001379286.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11930872..11935718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028457.6 → NP_001023628.1  putative Na(+)/H(+) antiporter nhx-9 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023628.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35449, Q95PV8, Q95PV9, Q95PW0
    Conserved Domains (1) summary
    pfam00999
    Location:44 → 443
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  2. NM_001028456.4 → NP_001023627.1  putative Na(+)/H(+) antiporter nhx-9 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023627.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35449
    Conserved Domains (1) summary
    pfam00999
    Location:24 → 423
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  3. NM_001392404.1 → NP_001379286.1  putative Na(+)/H(+) antiporter nhx-9 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    TIGR00840
    Location:9 → 471
    b_cpa1; sodium/hydrogen exchanger 3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35449.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous