sqst-1 ZZ-type domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sqst-1
Official Full Name: ZZ-type domain-containing protein
Primary source: WormBase:WBGene00011737
Locus tag: CELE_T12G3.1
See related: AllianceGenome:WB:WBGene00011737
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and protein kinase C binding activity. Predicted to be involved in aggrephagy; endosome organization; and mitophagy. Located in cytoplasm. Is expressed in several structures, including hypodermal cell; intestine; nervous system; pharynx; and reproductive system. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 3; distal myopathy with rimmed vacuoles; frontotemporal dementia and/or amyotrophic lateral sclerosis 3; and neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset. Orthologous to human SQSTM1 (sequestosome 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See sqst-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 3

Sequence:: Chromosome: IV; NC_003282.8 (12034282..12036891)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy.
Title: The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T12G3.1 (e-PCR)
- UniSTS:308018

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables K63-linked polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aggrephagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in aggresome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in amphisome	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ZZ-type domain-containing protein

NP_001255608.1

Confirmed by transcript evidence

NP_001255609.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

12034282..12036891

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268679.3 → NP_001255608.1 ZZ-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255608.1

Status: REVIEWED

UniProtKB/TrEMBL

Q22436

Conserved Domains (3) summary

smart00165
Location:657 → 692

UBA; Ubiquitin associated domain

cd02340
Location:182 → 224

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

pfam16788
Location:457 → 580

ATF7IP_BD; ATF-interacting protein binding domain
NM_001268680.3 → NP_001255609.1 ZZ-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255609.1

Status: REVIEWED

UniProtKB/TrEMBL

F1LIM5

Conserved Domains (3) summary

smart00165
Location:585 → 620

UBA; Ubiquitin associated domain

cd02340
Location:110 → 152

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

pfam16788
Location:385 → 508

ATF7IP_BD; ATF-interacting protein binding domain