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mig-32 Polycomb group RING finger protein 3 homolog mig-32 [ Caenorhabditis elegans ]

Gene ID: 178150, updated on 4-Jan-2025

Summary

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Official Symbol
mig-32
Official Full Name
Polycomb group RING finger protein 3 homolog mig-32
Primary source
WormBase:WBGene00008684
Locus tag
CELE_F11A10.3
See related
AllianceGenome:WB:WBGene00008684
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables histone ubiquitin ligase activity. Involved in several processes, including negative regulation of vulval development; nematode male tail tip morphogenesis; and regulation of axon extension involved in axon guidance. Located in nucleolus. Is expressed in several structures, including germ line and ventral ganglion. Orthologous to human PCGF3 (polycomb group ring finger 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mig-32 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (12089286..12092213, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene ncRNA Neighboring gene Transmembrane protein 115 Neighboring gene Cleavage and polyadenylation specificity factor subunit 4 Neighboring gene Protein ST7 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Trithorax, Hox, and TALE-class homeodomain proteins ensure cell survival through repression of the BH3-only gene egl-1. Potts MB, et al. Dev Biol, 2009 May 15. PMID 19254707
  2. MIG-32 and SPAT-3A are PRC1 homologs that control neuronal migration in Caenorhabditis elegans. Karakuzu O, et al. Development, 2009 Mar. PMID 19211678, Free PMC Article
  3. PRC1 chromatin factors strengthen the consistency of neuronal cell fate specification and maintenance in C. elegans. Bordet G, et al. PLoS Genet, 2022 May. PMID 35604893, Free PMC Article
  4. An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. McCracken S, et al. J Biol Chem, 2003 Nov 7. PMID 12944400
  5. Epigenetics in C. elegans: facts and challenges. Wenzel D, et al. Genesis, 2011 Aug. PMID 21538806

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables histone ubiquitin ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Polycomb group RING finger protein 3 homolog mig-32
NP_001255620.1
  • Confirmed by transcript evidence
NP_001255621.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12089286..12092213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268691.2 → NP_001255620.1  Polycomb group RING finger protein 3 homolog mig-32 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255620.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3YT24, Q19336
    Conserved Domains (2) summary
    cd16735
    Location:326 → 373
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd16102
    Location:459 → 545
    RAWUL_PCGF_like; RRING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in PCGF1-6, RING1 and -2, DRIP and similar proteins; structurally similar to a beta-grasp ubiquitin-like fold

  2. NM_001268692.3 → NP_001255621.1  Polycomb group RING finger protein 3 homolog mig-32 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255621.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3YT24
    Conserved Domains (1) summary
    cl28922
    Location:1 → 36
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein
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