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smz-1 PDZ domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178197, updated on 2-Nov-2024

Summary

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Official Symbol
smz-1
Official Full Name
PDZ domain-containing protein
Primary source
WormBase:WBGene00007733
Locus tag
CELE_C25G4.6
See related
AllianceGenome:WB:WBGene00007733
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in male meiosis chromosome segregation. Located in chromatin. Is expressed in male gonad and sperm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See smz-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (12455050..12456299)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ribosome-binding factor A Neighboring gene Condensin complex subunit dpy-26 Neighboring gene Transcription regulator spe-44 Neighboring gene Uncharacterized protein Neighboring gene BTB domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Requirement for the ERI/DICER complex in endogenous RNA interference and sperm development in Caenorhabditis elegans. Pavelec DM, et al. Genetics, 2009 Dec. PMID 19797044, Free PMC Article
  2. A specificity map for the PDZ domain family. Tonikian R, et al. PLoS Biol, 2008 Sep 30. PMID 18828675, Free PMC Article
  3. NHR-23 and SPE-44 regulate distinct sets of genes during Caenorhabditis elegans spermatogenesis. Ragle JM, et al. G3 (Bethesda), 2022 Nov 4. PMID 36135804, Free PMC Article
  4. The protein tyrosine phosphatase PPH-7 is required for fertility and embryonic development in C. elegans at elevated temperatures. Franziscus CA, et al. FEBS Open Bio, 2024 Mar. PMID 38320757, Free PMC Article
  5. Sperm chromatin proteomics identifies evolutionarily conserved fertility factors. Chu DS, et al. Nature, 2006 Sep 7. PMID 16943775, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in male meiosis chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
PDZ domain-containing protein
NP_502380.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12455050..12456299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069979.8 → NP_502380.1  PDZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502380.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18167
    Conserved Domains (2) summary
    cd00992
    Location:114 → 188
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00117
    Location:7 → 77
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
Nucleotide Protein
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