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wdfy-3 WD repeat and FYVE domain-containing protein 3 [ Caenorhabditis elegans ]

Gene ID: 178220, updated on 14-Nov-2024

Summary

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Official Symbol
wdfy-3
Official Full Name
WD repeat and FYVE domain-containing protein 3
Primary source
WormBase:WBGene00007752
Locus tag
CELE_C26H9A.2
See related
AllianceGenome:WB:WBGene00007752
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in protein localization. Predicted to be active in cytosol and membrane. Human ortholog(s) of this gene implicated in primary autosomal dominant microcephaly 18. Orthologous to human WDFY3 (WD repeat and FYVE domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See wdfy-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
36
Sequence:
Chromosome: IV; NC_003282.8 (12653401..12674769)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transcriptional regulator Neighboring gene V-type proton ATPase 116 kDa subunit a 4 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Prokaryotic-type class I peptide chain release factors domain-containing protein Neighboring gene Transcriptional regulator Neighboring gene PRotein arginine MethylTransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A null allele in the wdfy-3 selective autophagy gene of C. elegans . Buddell T, et al. MicroPubl Biol, 2022. PMID 35903777, Free PMC Article
  2. UNC-16 interacts with LRK-1 and WDFY-3 to regulate the termination of axon growth. Drozd CJ, et al. Genetics, 2024 Jun 5. PMID 38581414,
  3. SEL-2, the C. elegans neurobeachin/LRBA homolog, is a negative regulator of lin-12/Notch activity and affects endosomal traffic in polarized epithelial cells. de Souza N, et al. Development, 2007 Feb. PMID 17215302
  4. Human amyloid β peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans. Wang C, et al. Neurobiol Dis, 2018 Jan. PMID 28982592
  5. Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling. Lu N, et al. Mol Biol Cell, 2011 Feb 1. PMID 21148288, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UNC-16 interacts with LRK-1 and WDFY-3 to regulate the termination of axon growth.
    Title: UNC-16 interacts with LRK-1 and WDFY-3 to regulate the termination of axon growth.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WD repeat and FYVE domain-containing protein 3
NP_001255656.1
  • Confirmed by transcript evidence
NP_001255657.1
  • Confirmed by transcript evidence
NP_001255658.1
  • Confirmed by transcript evidence
NP_001255659.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12653401..12674769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268729.3 → NP_001255658.1  WD repeat and FYVE domain-containing protein 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255658.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2FLM3
    Conserved Domains (7) summary
    COG2319
    Location:2945 → 3149
    WD40; WD40 repeat [General function prediction only]
    cd01201
    Location:2423 → 2550
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    cd15719
    Location:3285 → 3349
    FYVE_WDFY3; FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar proteins
    pfam02138
    Location:2591 → 2871
    Beach; Beige/BEACH domain
    pfam16057
    Location:2179 → 2260
    DUF4800; Domain of unknown function (DUF4800)
    sd00039
    Location:2971 → 3010
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:2945 → 3150
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001268727.2 → NP_001255656.1  WD repeat and FYVE domain-containing protein 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255656.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFJ7
    Conserved Domains (7) summary
    COG2319
    Location:2941 → 3145
    WD40; WD40 repeat [General function prediction only]
    cd01201
    Location:2419 → 2546
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    cd15719
    Location:3281 → 3345
    FYVE_WDFY3; FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar proteins
    pfam02138
    Location:2587 → 2867
    Beach; Beige/BEACH domain
    pfam16057
    Location:2177 → 2258
    DUF4800; Domain of unknown function (DUF4800)
    sd00039
    Location:2967 → 3006
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:2941 → 3146
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001268728.4 → NP_001255657.1  WD repeat and FYVE domain-containing protein 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255657.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2FLM2
    Conserved Domains (7) summary
    COG2319
    Location:2943 → 3147
    WD40; WD40 repeat [General function prediction only]
    cd01201
    Location:2421 → 2548
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    cd15719
    Location:3283 → 3347
    FYVE_WDFY3; FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar proteins
    pfam02138
    Location:2589 → 2869
    Beach; Beige/BEACH domain
    pfam16057
    Location:2179 → 2260
    DUF4800; Domain of unknown function (DUF4800)
    sd00039
    Location:2969 → 3008
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:2943 → 3148
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_001268730.3 → NP_001255659.1  WD repeat and FYVE domain-containing protein 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255659.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2FLM1
    Conserved Domains (7) summary
    COG2319
    Location:2943 → 3147
    WD40; WD40 repeat [General function prediction only]
    cd01201
    Location:2421 → 2548
    PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins
    cd15719
    Location:3283 → 3347
    FYVE_WDFY3; FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar proteins
    pfam02138
    Location:2589 → 2869
    Beach; Beige/BEACH domain
    pfam16057
    Location:2177 → 2258
    DUF4800; Domain of unknown function (DUF4800)
    sd00039
    Location:2969 → 3008
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:2943 → 3148
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
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