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unc-31 Calcium-dependent secretion activator;PH domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178233, updated on 2-Nov-2024

Summary

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Official Symbol
unc-31
Official Full Name
Calcium-dependent secretion activator;PH domain-containing protein
Primary source
WormBase:WBGene00006767
Locus tag
CELE_ZK897.1
See related
AllianceGenome:WB:WBGene00006767
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cellular response to carbon dioxide; egg-laying behavior; and signal release. Located in several cellular components, including axon; dense core granule; and neuronal cell body. Is expressed in several structures, including egg-laying apparatus; excretory gland cell; nervous system; postcloacal sensillum; and rectal gland cell. Orthologous to several human genes including CADPS2 (calcium dependent secretion activator 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-31 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
23
Sequence:
Chromosome: IV; NC_003282.8 (12773867..12788354)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF1793 domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple excitatory and inhibitory neural signals converge to fine-tune Caenorhabditis elegans feeding to food availability. Dallière N, et al. FASEB J, 2016 Feb. PMID 26514165, Free PMC Article
  2. The C(2) and PH domains of CAPS constitute an effective PI(4,5)P2-binding unit essential for Ca(2+)-regulated exocytosis. Zhang L, et al. Structure, 2023 Apr 6. PMID 36863339
  3. UNC-31/CAPS docks and primes dense core vesicles in C. elegans neurons. Lin XG, et al. Biochem Biophys Res Commun, 2010 Jul 2. PMID 20515653
  4. Caenorhabditis elegans Male Copulation Circuitry Incorporates Sex-Shared Defecation Components To Promote Intromission and Sperm Transfer. LeBoeuf B, et al. G3 (Bethesda), 2017 Feb 9. PMID 28031243, Free PMC Article
  5. The Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions. Avery L, et al. Genetics, 1993 Jun. PMID 8325482, Free PMC Article

See all (130) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Four UNC-31 domains support distinct sequential molecular actions of UNC-31 in vesicular exocytosis, including steps in vesicle tethering and docking that bridge vesicle with plasma membrane.
    Title: UNC-31/CAPS docks and primes dense core vesicles in C. elegans neurons.
  2. CAPS function in dense core vesicle docking parallels UNC-13 in synaptic vesicle docking, which suggests that these related proteins act similarly to promote docking of independent vesicle populations.
    Title: CAPS and syntaxin dock dense core vesicles to the plasma membrane in neurons.
  3. UNC-31 is required for the docking of DCVs at the plasma membrane. Interestingly, the defect in DCV docking caused by UNC-31 mutation can be fully rescued by PKA activation.
    Title: PKA activation bypasses the requirement for UNC-31 in the docking of dense core vesicles from C. elegans neurons.
  4. Calcium activated protein for secretion (CAPS)/UNC-31 and UNC-13 serve parallel and dedicated roles in dense-core vesicle and synaptic vesicle exocytosis, respectively, in the C. elegans nervous system.
    Title: UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to carbon dioxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to salt IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dense core granule exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in dense core granule exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in larval feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of anterior/posterior axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in presynaptic dense core vesicle exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynaptic dense core vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of eating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of locomotion involved in locomotory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of muscle contraction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in serotonin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in ventral cord development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in dense core granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Calcium-dependent secretion activator;PH domain-containing protein
NP_001255663.1
  • Confirmed by transcript evidence
NP_001255664.1
  • Confirmed by transcript evidence
NP_001255665.1
  • Confirmed by transcript evidence
NP_001255666.1
  • Confirmed by transcript evidence
NP_001255667.1
  • Confirmed by transcript evidence
NP_001255668.1
  • Confirmed by transcript evidence
NP_001255669.1
  • Confirmed by transcript evidence
NP_001255670.1
  • Confirmed by transcript evidence
NP_001255671.1
  • Confirmed by transcript evidence
NP_001293901.1
  • Confirmed by transcript evidence
NP_001293902.1
  • Confirmed by transcript evidence
NP_001293903.1
  • Confirmed by transcript evidence
NP_001293904.1
  • Confirmed by transcript evidence
NP_001293905.1
  • Confirmed by transcript evidence
NP_001293906.1
  • Confirmed by transcript evidence
NP_001293907.1
  • Confirmed by transcript evidence
NP_001293908.1
  • Confirmed by transcript evidence
NP_001293909.1
  • Confirmed by transcript evidence
NP_001293910.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12773867..12788354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268737.4 → NP_001255666.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255666.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23658
    Conserved Domains (4) summary
    cd01234
    Location:575 → 697
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:582 → 685
    PH; PH domain
    pfam06292
    Location:894 → 985
    DUF1041; Domain of Unknown Function (DUF1041)
    cl14603
    Location:463 → 577
    C2; C2 domain

  2. NM_001268738.4 → NP_001255667.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255667.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23658
    Conserved Domains (4) summary
    cd01234
    Location:563 → 685
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:570 → 673
    PH; PH domain
    pfam06292
    Location:882 → 973
    DUF1041; Domain of Unknown Function (DUF1041)
    cl14603
    Location:451 → 565
    C2; C2 domain

  3. NM_001268735.4 → NP_001255664.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255664.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C1P637, D3YT40, D3YT41, D3YT42, D3YT43, Q23658
    Conserved Domains (4) summary
    cd01234
    Location:563 → 685
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:570 → 673
    PH; PH domain
    pfam06292
    Location:882 → 973
    DUF1041; Domain of Unknown Function (DUF1041)
    cl14603
    Location:451 → 565
    C2; C2 domain

  4. NM_001306972.3 → NP_001293901.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293901.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AKP8
    Conserved Domains (4) summary
    cd01234
    Location:582 → 704
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:589 → 692
    PH; PH domain
    pfam06292
    Location:901 → 996
    DUF1041; Domain of Unknown Function (DUF1041)
    cl14603
    Location:470 → 584
    C2; C2 domain

  5. NM_001306973.3 → NP_001293902.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293902.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ACM4
    Conserved Domains (4) summary
    cd01234
    Location:582 → 704
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:589 → 692
    PH; PH domain
    pfam06292
    Location:901 → 992
    DUF1041; Domain of Unknown Function (DUF1041)
    cl14603
    Location:470 → 584
    C2; C2 domain

  6. NM_001306974.3 → NP_001293903.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293903.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ADT8
    Conserved Domains (4) summary
    cd01234
    Location:575 → 697
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:582 → 685
    PH; PH domain
    pfam06292
    Location:894 → 989
    DUF1041; Domain of Unknown Function (DUF1041)
    cl14603
    Location:463 → 577
    C2; C2 domain

  7. NM_001306975.3 → NP_001293904.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293904.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ACJ2
    Conserved Domains (4) summary
    cd01234
    Location:575 → 697
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:582 → 685
    PH; PH domain
    pfam06292
    Location:894 → 985
    DUF1041; Domain of Unknown Function (DUF1041)
    cl14603
    Location:463 → 577
    C2; C2 domain

  8. NM_001306976.3 → NP_001293905.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293905.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AJ06
    Conserved Domains (4) summary
    cd01234
    Location:563 → 685
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:570 → 673
    PH; PH domain
    pfam06292
    Location:882 → 977
    DUF1041; Domain of Unknown Function (DUF1041)
    cl14603
    Location:451 → 565
    C2; C2 domain

  9. NM_001306977.3 → NP_001293906.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293906.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AKQ5
    Conserved Domains (4) summary
    cd01234
    Location:563 → 685
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:570 → 673
    PH; PH domain
    pfam06292
    Location:882 → 973
    DUF1041; Domain of Unknown Function (DUF1041)
    cl14603
    Location:451 → 565
    C2; C2 domain

  10. NM_001306978.3 → NP_001293907.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293907.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ACM9
    Conserved Domains (4) summary
    cd01234
    Location:570 → 692
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:577 → 680
    PH; PH domain
    pfam06292
    Location:889 → 984
    DUF1041; Domain of Unknown Function (DUF1041)
    cl14603
    Location:458 → 572
    C2; C2 domain

  11. NM_001268734.3 → NP_001255663.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255663.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G2V2
    Conserved Domains (4) summary
    cd01234
    Location:570 → 692
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:577 → 680
    PH; PH domain
    pfam06292
    Location:889 → 980
    DUF1041; Domain of Unknown Function (DUF1041)
    cl14603
    Location:458 → 572
    C2; C2 domain

  12. NM_001306979.3 → NP_001293908.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293908.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ADU4
    Conserved Domains (4) summary
    cd01234
    Location:563 → 685
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:570 → 673
    PH; PH domain
    pfam06292
    Location:882 → 977
    DUF1041; Domain of Unknown Function (DUF1041)
    cl14603
    Location:451 → 565
    C2; C2 domain

  13. NM_001306980.3 → NP_001293909.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293909.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ACJ8
    Conserved Domains (4) summary
    cd01234
    Location:551 → 673
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:558 → 661
    PH; PH domain
    pfam06292
    Location:870 → 965
    DUF1041; Domain of Unknown Function (DUF1041)
    cl14603
    Location:439 → 553
    C2; C2 domain

  14. NM_001268736.3 → NP_001255665.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255665.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G2V3
    Conserved Domains (4) summary
    cd01234
    Location:551 → 673
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:558 → 661
    PH; PH domain
    pfam06292
    Location:870 → 961
    DUF1041; Domain of Unknown Function (DUF1041)
    cl14603
    Location:439 → 553
    C2; C2 domain

  15. NM_001306981.3 → NP_001293910.1  PH domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293910.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AJ13
    Conserved Domains (4) summary
    cd01234
    Location:115 → 237
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:122 → 225
    PH; PH domain
    pfam06292
    Location:434 → 529
    DUF1041; Domain of Unknown Function (DUF1041)
    cl14603
    Location:3 → 117
    C2; C2 domain

  16. NM_001268739.3 → NP_001255668.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255668.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23658
    Conserved Domains (4) summary
    cd01234
    Location:115 → 237
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:122 → 225
    PH; PH domain
    pfam06292
    Location:434 → 525
    DUF1041; Domain of Unknown Function (DUF1041)
    cl14603
    Location:3 → 117
    C2; C2 domain

  17. NM_001268740.3 → NP_001255669.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255669.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23658
    Conserved Domains (4) summary
    cd01234
    Location:115 → 237
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:122 → 225
    PH; PH domain
    pfam06292
    Location:434 → 525
    DUF1041; Domain of Unknown Function (DUF1041)
    cl14603
    Location:3 → 117
    C2; C2 domain

  18. NM_001268741.3 → NP_001255670.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255670.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G3MU01

  19. NM_001268742.1 → NP_001255671.1  Calcium-dependent secretion activator [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255671.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23658
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23658.6

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