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dod-22 CUB-like domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178247, updated on 9-Dec-2024

Summary

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Official Symbol
dod-22
Official Full Name
CUB-like domain-containing protein
Primary source
WormBase:WBGene00010125
Locus tag
CELE_F55G11.5
See related
AllianceGenome:WB:WBGene00010125
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in defense response to Gram-negative bacterium and innate immune response. Is expressed in head neurons; intestine; and rectal gland cell. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dod-22 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (12965374..12967392)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene CUB-like domain-containing protein Neighboring gene CUB-like domain-containing protein Neighboring gene CUB-like domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vibrio cholerae hemolysin is required for lethality, developmental delay, and intestinal vacuolation in Caenorhabditis elegans. Cinar HN, et al. PLoS One, 2010 Jul 13. PMID 20644623, Free PMC Article
  2. Caenorhabditis elegans LIN-24, a homolog of bacterial pore-forming toxin, protects the host from microbial infection. Zhang H, et al. FASEB J, 2023 Oct. PMID 37682220
  3. Biosafety assessment of Acinetobacter strains isolated from the Three Gorges Reservoir region in nematode Caenorhabditis elegans. Deng Y, et al. Sci Rep, 2021 Oct 5. PMID 34611259, Free PMC Article
  4. Genomic analysis of immune response against Vibrio cholerae hemolysin in Caenorhabditis elegans. Sahu SN, et al. PLoS One, 2012. PMID 22675448, Free PMC Article
  5. Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family. Greiss S, et al. BMC Genomics, 2008 Jul 15. PMID 18627611, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response HEP PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
CUB-like domain-containing protein
NP_001255689.1
  • Confirmed by transcript evidence
NP_001255690.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12965374..12967392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268760.2 → NP_001255689.1  CUB-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255689.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XUE0
    Conserved Domains (2) summary
    pfam02408
    Location:15 → 132
    CUB_2; CUB-like domain
    cl21464
    Location:223 → 340
    cupin_like; Conserved domain found in cupin and related proteins

  2. NM_001268761.3 → NP_001255690.1  CUB-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255690.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D5MCV0
    Conserved Domains (2) summary
    pfam02408
    Location:1 → 90
    CUB_2; CUB-like domain
    cl21464
    Location:181 → 298
    cupin_like; Conserved domain found in cupin and related proteins
Nucleotide Protein
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