crld-1 Protein disulfide isomerase crld-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: crld-1
Official Full Name: Protein disulfide isomerase crld-1
Primary source: WormBase:WBGene00008624
Locus tag: CELE_F09E8.2
See related: AllianceGenome:WB:WBGene00008624
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum lumen and endoplasmic reticulum membrane. Is expressed in several structures, including body wall musculature; gonad; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in atrioventricular septal defect and heart septal defect. Orthologous to human CRELD1 (cysteine rich with EGF like domains 1) and CRELD2 (cysteine rich with EGF like domains 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See crld-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 11

Sequence:: Chromosome: IV; NC_003282.8 (13150597..13154441, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In a forward genetic screen conducted in the nematode Caenorhabditis elegans, the authors identified crld-1 as a gene required for the synaptic expression of ionotropic acetylcholine receptors (AChR).
Title: CRELD1 is an evolutionarily-conserved maturational enhancer of ionotropic acetylcholine receptors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F09E8.2 (e-PCR)
- UniSTS:319226

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables protein disulfide isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein disulfide isomerase crld-1

NP_001379479.1

Confirmed by transcript evidence

NP_502530.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

13150597..13154441 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392424.1 → NP_001379479.1 Protein disulfide isomerase crld-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

smart00179
Location:241 → 282

EGF_CA; Calcium-binding EGF-like domain

pfam11938
Location:26 → 128

DUF3456; TLR4 regulator and MIR-interacting MSAP
NM_070129.8 → NP_502530.1 Protein disulfide isomerase crld-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502530.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A7LPH5, Q19267

Conserved Domains (3) summary

smart00179
Location:241 → 282

EGF_CA; Calcium-binding EGF-like domain

smart00261
Location:205 → 239

FU; Furin-like repeats

pfam11938
Location:26 → 128

DUF3456; TLR4 regulator and MIR-interacting MSAP