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tlp-1 Zinc finger protein tlp-1 [ Caenorhabditis elegans ]

Gene ID: 178338, updated on 14-Nov-2024

Summary

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Official Symbol
tlp-1
Official Full Name
Zinc finger protein tlp-1
Primary source
WormBase:WBGene00006580
Locus tag
CELE_T23G4.1
See related
AllianceGenome:WB:WBGene00006580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including head; rectal valve cell; somatic nervous system; tail precursor cell; and tail spike. Orthologous to human ZNF503 (zinc finger protein 503) and ZNF703 (zinc finger protein 703). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tlp-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (13701208..13704082, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TLP-1 is an asymmetric cell fate determinant that responds to Wnt signals and controls male tail tip morphogenesis in C. elegans. Zhao X, et al. Development, 2002 Mar. PMID 11880358
  2. Conserved gene regulatory module specifies lateral neural borders across bilaterians. Li Y, et al. Proc Natl Acad Sci U S A, 2017 Aug 1. PMID 28716930, Free PMC Article
  3. The C. elegans RUNX transcription factor RNT-1/MAB-2 is required for asymmetrical cell division of the T blast cell. Kagoshima H, et al. Dev Biol, 2005 Nov 15. PMID 16226243
  4. The nuclear receptor NHR-25 cooperates with the Wnt/beta-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans. Hajduskova M, et al. J Cell Sci, 2009 Sep 1. PMID 19654209, Free PMC Article
  5. tcl-2 encodes a novel protein that acts synergistically with Wnt signaling pathways in C. elegans. Zhao X, et al. Dev Biol, 2003 Apr 15. PMID 12679102

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zinc finger protein tlp-1
NP_502647.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13701208..13704082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070246.5 → NP_502647.1  Zinc finger protein tlp-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502647.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGF8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EGF8.1

Gene LinkOut

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