ccar-1 DBC1/CARP1 catalytically inactive NUDIX hydrolase domain-containing protein;SAP domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ccar-1
Official Full Name: DBC1/CARP1 catalytically inactive NUDIX hydrolase domain-containing protein;SAP domain-containing protein
Primary source: WormBase:WBGene00003085
Locus tag: CELE_Y37A1B.1
See related: AllianceGenome:WB:WBGene00003085
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable hydrolase activity. Involved in hemidesmosome assembly. Predicted to be located in cytoplasm and membrane. Predicted to be active in nucleus. Is expressed widely. Orthologous to several human genes including CCAR1 (cell division cycle and apoptosis regulator 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ccar-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 9

Sequence:: Chromosome: IV; NC_003282.8 (14071548..14076742)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing.
Title: CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing.
CCAR-1 physically interacts with HRP-2, a splicing factor known to mediate unc-52 alternative splicing to control the proportions of different UNC-52 isoforms and stabilize hemidesmosomes .
Title: CCAR-1 affects hemidesmosome biogenesis by regulating unc-52/perlecan alternative splicing in the C. elegans epidermis.
knockdown of CCAR-1 via ccar-1 RNAi works through SIR-2.1 to enhance stress resistance, motility, longevity, and proteostasis.
Title: CCAR-1 is a negative regulator of the heat-shock response in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y37A1B.1 (e-PCR)
- UniSTS:312830

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in hemidesmosome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DBC1/CARP1 catalytically inactive NUDIX hydrolase domain-containing protein;SAP domain-containing protein

NP_001255780.1

Confirmed by transcript evidence

NP_001305185.1

Confirmed by transcript evidence

NP_001305188.1

Confirmed by transcript evidence

NP_001379396.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

14071548..14076742

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001318256.5 → NP_001305185.1 SAP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S4XR43

Conserved Domains (6) summary

smart00513
Location:654 → 687

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PLN03124
Location:655 → 723

PLN03124; poly [ADP-ribose] polymerase; Provisional

PHA03307
Location:196 → 308

PHA03307; transcriptional regulator ICP4; Provisional

TIGR04523
Location:1051 → 1125

Mplasa_alph_rch; helix-rich Mycoplasma protein

pfam14443
Location:442 → 551

DBC1

pfam14444
Location:101 → 158

S1-like
NM_001392438.1 → NP_001379396.1 DBC1/CARP1 catalytically inactive NUDIX hydrolase domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EBS4

Conserved Domains (3) summary

PHA03307
Location:196 → 308

PHA03307; transcriptional regulator ICP4; Provisional

pfam14443
Location:439 → 500

DBC1

pfam14444
Location:101 → 158

S1-like
NM_001268851.3 → NP_001255780.1 DBC1/CARP1 catalytically inactive NUDIX hydrolase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255780.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KMJ3

Conserved Domains (3) summary

PHA03307
Location:196 → 308

PHA03307; transcriptional regulator ICP4; Provisional

pfam14443
Location:442 → 551

DBC1

pfam14444
Location:101 → 158

S1-like
NM_001318259.3 → NP_001305188.1 SAP domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S4XRD3

Conserved Domains (2) summary

smart00513
Location:30 → 63

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

PLN03124
Location:31 → 99

PLN03124; poly [ADP-ribose] polymerase; Provisional