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gdi-1 Rab GDP dissociation inhibitor [ Caenorhabditis elegans ]

Gene ID: 178402, updated on 2-Nov-2024

Summary

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Official Symbol
gdi-1
Official Full Name
Rab GDP dissociation inhibitor
Primary source
WormBase:WBGene00001558
Locus tag
CELE_Y57G11C.10
See related
AllianceGenome:WB:WBGene00001558
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable Rab GDP-dissociation inhibitor activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in anchor cell. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability; non-syndromic X-linked intellectual disability 41; and psychotic disorder. Orthologous to human GDI1 (GDP dissociation inhibitor 1) and GDI2 (GDP dissociation inhibitor 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gdi-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (14790818..14792887, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cyclin N-terminal domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Neuropeptide-Like Protein Neighboring gene RRM domain-containing protein Neighboring gene Ubiquinone biosynthesis O-methyltransferase, mitochondrial Neighboring gene Protein BRICK1 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Searching for signaling balance through the identification of genetic interactors of the Rab guanine-nucleotide dissociation inhibitor gdi-1. Lee AY, et al. PLoS One, 2010 May 13. PMID 20498707, Free PMC Article
  2. GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans. Yin J, et al. J Cell Biol, 2017 Jun 5. PMID 28424218, Free PMC Article
  3. A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation. Lohmer LL, et al. PLoS Genet, 2016 Jan. PMID 26765257, Free PMC Article
  4. Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation. Gomez F, et al. Gene, 2012 Sep 10. PMID 22735617, Free PMC Article
  5. Caenorhabditis elegans SAND-1 is essential for RAB-7 function in endosomal traffic. Poteryaev D, et al. EMBO J, 2007 Jan 24. PMID 17203072, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We also characterized a novel invadopodia regulator, gdi-1 (Rab GDP dissociation inhibitor), which mediates membrane trafficking. We show that GDI-1 functions in the anchor cell to promote invadopodia formation.
    Title: A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation.
  2. Genetic interactors of gdi-1, the orthologue of GDI1, a gene associated with mental retardation in human, were identified.
    Title: Searching for signaling balance through the identification of genetic interactors of the Rab guanine-nucleotide dissociation inhibitor gdi-1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GDP-dissociation inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables Rab GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Rab GDP-dissociation inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rab GDP dissociation inhibitor
NP_001041043.1
  • Confirmed by transcript evidence
NP_001041044.1
  • Confirmed by transcript evidence
NP_001255836.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    14790818..14792887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047578.5 → NP_001041043.1  Rab GDP dissociation inhibitor [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041043.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBR1
    Conserved Domains (1) summary
    cl21454
    Location:1 → 434
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_001047579.7 → NP_001041044.1  Rab GDP dissociation inhibitor [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041044.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2V4S2
    Conserved Domains (1) summary
    cl21454
    Location:1 → 449
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. NM_001268907.3 → NP_001255836.1  Rab GDP dissociation inhibitor [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255836.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E9P8A8
    Conserved Domains (1) summary
    cl21454
    Location:2 → 93
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
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