mel-46 ATP-dependent RNA helicase;Helicase C-terminal domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mel-46
Official Full Name: ATP-dependent RNA helicase;Helicase C-terminal domain-containing protein
Primary source: WormBase:WBGene00020284
Locus tag: CELE_T06A10.1
See related: AllianceGenome:WB:WBGene00020284
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in spliceosomal snRNP assembly. Predicted to be located in P granule. Predicted to be part of SMN complex. Is expressed in germ line. Orthologous to human DDX20 (DEAD-box helicase 20). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mel-46 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 10

Sequence:: Chromosome: IV; NC_003282.8 (16855044..16863481, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Collectively, these results suggest decreased SMN leads to defective microRNA function via MEL-46 misregulation, followed by increased M2 muscarinic receptor expression, and neuronal dysfunction in Spinal Muscular Atrophy.
Title: Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models.
mel-46 encodes a DEAD box protein that is required maternally for early embryogenesis and zygotically for postembryonic development
Title: The DEAD-box protein MEL-46 is required in the germ line of the nematode Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T06A10.2 (e-PCR)
- UniSTS:322304

T06A10.1 (e-PCR)
- UniSTS:312748

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in spliceosomal snRNP assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in P granule	IEA Inferred from Electronic Annotation more info
part_of SMN complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ATP-dependent RNA helicase;Helicase C-terminal domain-containing protein

NP_001255909.1

Confirmed by transcript evidence

NP_001255911.1

Confirmed by transcript evidence

NP_001380107.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

16855044..16863481 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268980.4 → NP_001255909.1 ATP-dependent RNA helicase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255909.1

Status: REVIEWED

UniProtKB/TrEMBL

G5ED26

Conserved Domains (3) summary

PTZ00121
Location:429 → 882

PTZ00121; MAEBL; Provisional

cd18787
Location:235 → 363

SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases

cd17943
Location:33 → 224

DEADc_DDX20; DEAD-box helicase domain of DEAD box protein 20
NM_001392452.1 → NP_001380107.1 Helicase C-terminal domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2KAP9
NM_001268982.3 → NP_001255911.1 Helicase C-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255911.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KAQ0

Conserved Domains (2) summary

PTZ00121
Location:184 → 637

PTZ00121; MAEBL; Provisional

cd18787
Location:5 → 118

SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases