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nep-23 NEPrilysin metallopeptidase family [ Caenorhabditis elegans ]

Gene ID: 178472, updated on 2-Nov-2024

Summary

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Official Symbol
nep-23
Official Full Name
NEPrilysin metallopeptidase family
Primary source
WormBase:WBGene00013785
Locus tag
CELE_Y116A8C.4
See related
AllianceGenome:WB:WBGene00013785
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human KEL (Kell metallo-endopeptidase (Kell blood group)) and ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nep-23 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
13
Sequence:
Chromosome: IV; NC_003282.8 (16920341..16924118)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Stress-associated endoplasmic reticulum protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene NEPrilysin metallopeptidase family

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NEPrilysin metallopeptidase family
NP_503004.2
  • Product from WormBase gene class nep;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    16920341..16924118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070603.5 → NP_503004.2  NEPrilysin metallopeptidase family [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503004.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U2T1
    Conserved Domains (1) summary
    cd08662
    Location:96 → 711
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
Nucleotide Protein
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