cnnm-1 Metal transporter cnnm-1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: cnnm-1
Official Full Name: Metal transporter cnnm-1
Primary source: WormBase:WBGene00016879
Locus tag: CELE_C52D10.12
See related: AllianceGenome:WB:WBGene00016879
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable transmembrane transporter activity. Involved in several processes, including determination of adult lifespan; magnesium ion homeostasis; and positive regulation of vulval development. Located in basolateral plasma membrane. Is expressed in several structures, including body wall musculature; hypodermis; intestine; pharynx; and rectum. Human ortholog(s) of this gene implicated in Jalili syndrome and renal hypomagnesemia 6. Orthologous to several human genes including CNNM1 (cyclin and CBS domain divalent metal cation transport mediator 1); CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2); and CNNM3 (cyclin and CBS domain divalent metal cation transport mediator 3). [provided by Alliance of Genome Resources, Jan 2025]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See cnnm-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 10

Sequence:: Chromosome: IV; NC_003282.8 (17197911..17206845, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

he results revealed that RNAi-mediated inactivation of several genes restores gonad elongation, including aak-2, which encodes the catalytic subunit of AMP-activated protein kinase (AMPK). We then generated triple mutant worms for cnnm-1; cnnm-3; aak-2 and confirmed that the aak-2 mutation also suppressed the defective gonadal elongation in cnnm-1; cnnm-3 mutant worms.
Title: Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

C52D10.12 (e-PCR)
- UniSTS:319160

Y116A8B.3 (e-PCR)
- UniSTS:313574

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in magnesium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in magnesium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in magnesium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in magnesium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gonad development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gonad development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to magnesium ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Metal transporter cnnm-1

NP_503052.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

17197911..17206845 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_070651.6 → NP_503052.1 Metal transporter cnnm-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503052.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A3QM97

Conserved Domains (3) summary

COG0517
Location:390 → 519

CBS; CBS domain [Signal transduction mechanisms]

cd04590
Location:399 → 521

CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...

pfam01595
Location:203 → 365

DUF21; Domain of unknown function DUF21