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cul-3 Cullin family profile domain-containing protein;Cullin neddylation domain-containing protein;Cullin-3 [ Caenorhabditis elegans ]

Gene ID: 178547, updated on 9-Dec-2024

Summary

Official Symbol
cul-3
Official Full Name
Cullin family profile domain-containing protein;Cullin neddylation domain-containing protein;Cullin-3
Primary source
WormBase:WBGene00000838
Locus tag
CELE_Y108G3AL.1
See related
AllianceGenome:WB:WBGene00000838
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables POZ domain binding activity. Involved in several processes, including programmed cell death involved in cell development; protein polyubiquitination; and striated muscle myosin thick filament assembly. Part of Cul3-RING ubiquitin ligase complex. Is expressed in several structures, including anal depressor muscle; intestine; pharynx; reproductive system; and tail. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See cul-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (177579..185100)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Pre-mRNA-splicing factor 38 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AT-rich interactive domain-containing protein arid-1 Neighboring gene Trafficking protein particle complex subunit

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables POZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Cullin family profile domain-containing protein;Cullin neddylation domain-containing protein;Cullin-3
NP_001300214.1
  • Confirmed by transcript evidence
NP_001300215.1
  • Confirmed by transcript evidence
NP_001300216.1
  • Confirmed by transcript evidence
NP_503151.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    177579..185100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070750.8NP_503151.1  Cullin-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503151.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17391, Q95Y32
    Conserved Domains (3) summary
    smart00182
    Location:427567
    CULLIN; Cullin
    pfam00888
    Location:32674
    Cullin; Cullin family
    pfam10557
    Location:709769
    Cullin_Nedd8; Cullin protein neddylation domain
  2. NM_001313285.3NP_001300214.1  Cullin family profile domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AY70
    Conserved Domains (2) summary
    pfam00888
    Location:1615
    Cullin; Cullin family
    pfam10557
    Location:649707
    Cullin_Nedd8; Cullin protein neddylation domain
  3. NM_001313286.3NP_001300215.1  Cullin family profile domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ASX8
    Conserved Domains (1) summary
    COG5647
    Location:1240
    COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
  4. NM_001313287.2NP_001300216.1  Cullin neddylation domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AV81
    Conserved Domains (1) summary
    COG5647
    Location:3113
    COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]