atg-9 Autophagy-related protein 9 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: atg-9
Official Full Name: Autophagy-related protein 9
Primary source: WormBase:WBGene00020706
Locus tag: CELE_T22H9.2
See related: AllianceGenome:WB:WBGene00020706
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in regulation of presynapse assembly. Located in cytoplasm and presynapse. Is expressed in several structures, including AIY; hypodermis; nerve ring; neuronal sheath cell; and spermatheca. Orthologous to several human genes including ATG9A (autophagy related 9A). [provided by Alliance of Genome Resources, Jan 2025]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See atg-9 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 11

Sequence:: Chromosome: V; NC_003283.11 (349385..359658)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The active zone protein CLA-1 (Clarinet) bridges two subsynaptic domains to regulate presynaptic sorting of ATG-9.
Title: The active zone protein CLA-1 (Clarinet) bridges two subsynaptic domains to regulate presynaptic sorting of ATG-9.
The autophagy protein ATG9A enables lipid mobilization from lipid droplets.
Title: The autophagy protein ATG9A enables lipid mobilization from lipid droplets.
RAB-10 GTPase cycling was required to control the size of GFP::ATG-9 foci. Collectively, these data support a model where rab-10 controls autophagic flux by regulating autophagosome formation and maturation.
Title: The recycling endosome protein RAB-10 promotes autophagic flux and localization of the transmembrane protein ATG-9.
findings indicate that autophagy is spatially regulated in neurons through the transport of ATG-9 by KIF1A/UNC-104 to regulate neurodevelopment
Title: KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

T22H9.2 (e-PCR)
- UniSTS:319672

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site membrane	IEA Inferred from Electronic Annotation more info
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Autophagy-related protein 9

NP_001364810.1

Confirmed by transcript evidence

NP_503178.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

349385..359658

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_070777.5 → NP_503178.2 Autophagy-related protein 9 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q3T903, Q9TXN6

Conserved Domains (1) summary

pfam04109
Location:236 → 589

APG9; Autophagy protein Apg9
NM_001377584.1 → NP_001364810.1 Autophagy-related protein 9 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2L0M4